UoB BMVP Michael T. Davies-Coleman, Departmental Lecture: Halogenated marine natural products. From the sea floor and into the atmosphere

26 July 2018, 12.00 PM - 26 July 2018, 1.00 PM

UoB BMVP Michael T. Davies-Coleman, University of the Western Cape, South Africa

Lecture Theatre 4, Chemistry Building, Cantock's Close, BS8 1TH

Professor Mike Davies-Coleman joined the University of Western Cape in June 2012 as the Dean of Natural Sciences. Professor Davies-Coleman moved to UWC from Rhodes University in the Eastern Cape where he was Professor of Organic Chemistry and a former Head of the Department. In addition to over two decades of experience teaching organic chemistry in the Department of Chemistry he also lectured for several years in the School of Pharmacy at Rhodes University at the beginning of his academic career. His research interests, while specializing in marine natural products chemistry, have encompassed synthetic organic chemistry, nuclear magnetic resonance spectroscopy, marine invertebrate biology and taxonomy, microbiology, biochemistry and pharmacology.

Approximately 5000 halogenated natural products are known, the vast majority of which are biosynthesized by marine organisms. New bioactive halogenated marine natural products are regularly isolated and identified when extracts of marine organisms are subjected to mass spectroscopic analysis, simple antimicrobial bioassays, ecologically relevant bioassays, and cancer cell line and isolated protein target screening programmes.

Selected examples of the structurally diverse halogenated bioactive marine natural products, identified from application of these techniques to extracts of marine invertebrates and algae collected off the coasts of South Africa and the central Pacific island nation of Palau, will be highlighted.

Of interest to atmospheric chemists is the contribution of previously unknown sources of mono- and polyhalogenated volatile marine natural products to inter alia tropospheric and stratospheric ozone depletion events. Very little is known about the contribution of volatile halocarbons, emerging from the vast southern oceans, to our understanding of the global atmospheric halide budget.

The preliminary time series data for ca. 30 volatile halocarbons, the first data set of this kind from Africa, acquired from a joint University of Bristol/University of Western Cape volatile marine halocarbon programme based at Cape Point, South Africa, will be presented.

In association with the Cabot Institute

 

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