Dr David Matthews

Reader in Virology

School of Cellular and Molecular Medicine,
University of Bristol, Biomedical Sciences Building,
Bristol, BS8 1TD

phone: +44 (0)117 33 12058 (internal 12058)
email: d.a.matthews@bristol.ac.uk

Research interests

I am primarily interested in virus host cell interactions with an emphasis on respiratory viruses, in particular adenovirus, but also respiratory syncytial virus, influenza and Hendra virus.  I have been looking at how these viruses interact with the host cell using state of the art techniques including laser confocal microscopy, high throughput quantitative mass spectrometry and Deep Sequencing (or Next Generation Sequencing) of virus infected cells.  In collaboration with Dr Davidson here at Bristol we also apply these techniques to the study of Dengue virus.

Most recently we have become very interested in the study of novel zoonotic agents such as Hendra, MERS and Ebola.  We are at the forefront of developing novel intergrated high throughput methods to study these very dangerous viruses in their natural hosts (bats) to try to understand why they are apparently harmless to their natural host but highly lethal in humans.

In addition, we also use these high throughput approaches to study recombinant gene therapy systems (especially adenovirus based ones).  This includes an emphasis on the molecular basis of oncolytic or cancer killing adenoviruses.

Selected publications

View all publications for Dr Matthews on his Bristol Research Profile page