Biotechnology

Ref: 890 -  Human Podocyte cell line

Originally developed by Prof Saleem and colleagues at the University of Bristol, the colloquially named ‘Saleemocyte’ is known and used world-wide. It is a unique and representative tool for the study of human glomerular disease in-vitro.

The conditionally immortalised podocyte cell line allows an in-vitro process of maturation analogous to the development and maturation of podocytes in-vivo. The result is a homogenous, stable cell source that shows expression of key antigenic markers of differentiated in vivo podocytes. These include the novel podocyte proteins nephrin, podocin, CD2AP and synapodin.

Download more information here 890 (PDF, 225kB)‌ or contact: Andrew.Wilson@bris.ac.uk.

Ref: 1528 - Novel Product for the Alleviation of Symptom 'flare-up' in Chronic Intestinal Disease

We have identified a strain of Streptococcus thermophilus (NCIMB 41856) which is anti-inflammatory, acting on both human intestinal leukocytes and human intestinal epithelial cell lines (Caco-2 and T84). It reduces epithelial cell death as well as NF-κB signalling and IL-8 production triggered by pathogens. It abrogates binding of pathogens to epithelial cells and crosses the epithelial cell barrier with E. coli where it downregulates Th1 and Th17 responses in intestinal leukocytes. Its mode of action is local to the treated area, avoiding the immunosuppression seen with systemic medication.

For more information click here 1528 (PDF, 243kB)‌ or contact laura.newell@bristol.ac.uk.

Ref: 1814 - Sampling Device

The collection of numerous biological samples from a patient (microdialysates, blood etc.) has long been a challenge to both clinician and patient. In the artificial and stressful hospital environment, discomfort to the patient may result in levels of samples collected not being representative of levels in a patient’s everyday life. University of Bristol researchers have created a simple, portable, and compact device in which biological samples can be discretely collected at set intervals. Removing the need for a hospital setting, this device enables the patent to undertake normal activities with samples collected for prolonged periods of time. 

For more information click here 1814 (PDF, 247kB)‌ or contact laura.newell@bristol.ac.uk.

Ref: 1976 - New materials for targeted vaccine delivery

Researchers at Bristol have developed a toolkit of α-helical coiled coil peptide modules as building blocks for creating self-assembling biomimetic structures. The latest designed structures are hollow spheres (~100 nm in diameter) constructed from simple peptide modules, which when mixed form hexagonal lattices that close to form cages. The new structures (SAGEs) mimic those in natural en-capsulation systems, like virus capsids. The SAGEs offer the poten-tial for simple, reproducible presentation and/or encapsulation and release systems for controlled delivery of vaccines and drugs.

Download more information here 1976 (PDF, 217kB)‌ or contact: rosalind.darby@bristol.ac.uk

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