The Koh Laboratory is interested in exploring and exploiting molecular aberrations in tumour and its microenvironment. Through integrated use of omics profiling, imaging, molecular biology, pharmacology and AI-aided computational approaches, we study how deregulated biological pathways, both within tumour and its microenvironmental counterparts such as immune cells, mediate disease progression. We leverage these mechanistic insights to identify actionable tumour-specific vulnerabilities. Our goal is to develop selective, synergistic treatment strategies that enable maximal tumour-cell killing and minimal host toxicity.

Enquiries from prospective graduate students and postdoctoral researchers are welcome.