
Dr Ross Purple
BSc(Lond.), DPhil
Current positions
Research Fellow
School of Physiology, Pharmacology & Neuroscience
Contact
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Research interests
Sleep is a fundamental brain state required for a range of processes, facilitating everything from cellular regeneration and immune function to emotional regulation and memory processing. Disrupted sleep therefore has substantial effects on our health and is associated with many, if not all, mental health disorders.
One of the key functions of sleep is to provide optimal conditions for consolidating memory, strengthening and incorporating salient experiences with existing memories for long-term storage, whilst weakening unnecessary information. This function may be especially crucial for processing emotional memories, including traumatic experiences. My research focuses on understanding how sleep facilitates the processing of traumatic experiences using a range of techniques including electrophysiology, brain stimulation, and machine learning. By exploring how sleep modulates emotional memory processing, we aim to uncover novel therapeutic applications that harness sleep to improve resilience and reduce the risk of trauma-related disorders such as post-traumatic stress disorder (PTSD).
Biography
In 2013, I began my DPhil education at the University of Oxford where I studied sleep and circadian rhythms in individuals at high risk for developing psychosis, supervised by Drs Katharina Wulff, Vladyslav Vyazovskiy, and Kate Porcheret. In 2017, I joined the group of Professor Matt Jones at the University of Bristol where I used in-vivo electrophysiological techniques to study cell assemblies, groups of neurons that temporally and functionally organize to encode and store information. I am now an MRC CDA Research Fellow at the University of Bristol with my lab focused on the role of sleep for processing emotional memories.
Projects and supervisions
Research projects
Sleep as a therapeutic target for enhancing resilience to traumatic experience
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
04/11/2024 to 03/11/2029
Thesis supervisions
Publications
Recent publications
06/09/2024Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function
Science Advances
Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis
Sleep
The GABA A receptor modulator zolpidem augments hippocampal-prefrontal coupling during non-REM sleep
Neuropsychopharmacology
Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences?
Translational Psychiatry
Sleep-related memory consolidation in the psychosis spectrum phenotype
Neurobiology of Learning and Memory