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Dr Jennifer Bailey

Dr Jennifer Bailey

Dr Jennifer Bailey
PhD, BSc (Hons)

Honorary Lecturer

Senior Associate Teacher

Area of research

Factors causing the development of fibrosis in inflammatory bowel disease and therapeutic anti-inflammatory agents

Langford House,
Langford, North Somerset BS40 5DU
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Summary

The focus of my research is inflammatory bowel disease (IBD), in particular factors which cause the development of inflammation-induced fibrosis and therapeutic anti-inflammatory agents. There are two arms to my work:

1) An iron-responsive probiotic. This project is developing an iron and stress-responsive probiotic for use in treating inflammatory bowel disease in animals and humans. Work is ongoing to further assess the anti-inflammatory properties of this probiotic and determine how these can best be harnessed to treat disease.

 

Science Yoghurt

 

2) The role of IL-13 in the development of fibrotic strictures in Crohn's disease. IL-13 is known to have a role in fibrosis. I have found it to be increased in the intestines of Crohn's disease patients and have identified a novel population of cells, showing some characteristics of innate lymphoid cells, which are able to produce IL-13 and are abundant in fibrotic intestinal muscle. Work is ongoing to further characterise these cells and assess their potential as a therapeutic target.

 

 ILC Pure

 

Further information about Dr Jenny Bailey can be found here.

Biography

Teaches
BSc Veterinary Nursing and Bioveterinary Science

Jenny graduated from the University of Bristol with a degree in Veterinary Pathogenesis in 2004 before undertaking a PhD, also at Bristol, on the interactions between immune cells and stromal cells in the development of mucosal immunity in pigs; this degree was awarded in 2009. Since then, her research career has concentrated on factors which promote gastrointestinal health in both humans and animals, with a particular focus on gut barrier function and inflammatory bowel disease.

Recent publications

View complete publications list in the University of Bristol publications system

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