Professor Graham Collingridge

Research summary

The laboratory is interested in synaptic mechanisms and, in particular, synaptic plasticity in the mammalian central nervous system. Synaptic plasticity is the process by which synapses alter their efficiency and this property is used by the nervous system to store information. Synaptic plasticity is therefore a fundamental property of the brain involved in the development of the nervous system, learning & memory and other cognitive processes. Dysfunction of synaptic plastic processes is believed to be involved in various psychiatric and neurological disorders, including epilepsy and ischaemic brain injury. By elucidating the mechanisms of synaptic plasticity at a molecular level we ...

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Selected publications

• Nicolas, C, Peineau, S, Amici, M, Csaba, Z, Fafouri, A, Javalet, C, Collett, V, Hildebrandt, L, Seaton, G, Choi, S-L, Sim, S-E, Bradley, C, Lee, K, Zhuo, M, Kaang, B-K, Gressens, P, Dournaud, P, Fitzjohn, SM, Bortolotto, Z, Cho, K & Collingridge, G, 2012, ‘The JAK/STAT pathway is involved in synaptic plasticity’. Neuron, vol 73., pp. 374 - 390
• Kim, JL, Lee, HR, Sim, SE, Baek, J, Yu, NK, Choi, JH, Ko, HG, Lee, YS, Park, SW, Kwak, C, Ahn, SJ, Choi, SY, Kim, H, Kim, KH, Backx, PH, Bradley, CA, Kim, E, Jang, DJ, Lee, K, Kim, SJ, Zhuo, M, Collingridge, G & Kaang, BK, 2011, ‘PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility’. Nature Neuroscience, vol 14., pp. 1447 - 1454

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Recent publications

• Park, P, Kang, H, Sanderson, T, Bortolotto, Z, Georgiou, J, Zhuo, M, Collingridge, G & Kaang, B-K, 2019, ‘On the role of calcium-permeable AMPARs in long-term potentiation and synaptic tagging in the rodent hippocampus’. Frontiers in Synaptic Neuroscience, vol 11.
• Irvine, MW, Fang, G, Sapkota, K, Burnell, ES, Volianskis, A, Costa, BM, Culley, G, Collingridge, GL, Monaghan, DT & Jane, DE, 2019, ‘Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid’. European Journal of Medicinal Chemistry, vol 164., pp. 471-498

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View complete publications list in the University of Bristol publications system