Professor David Jane

Research summary

Glutamate receptors are the major excitatory synaptic receptors in brain and spinal cord. They are of two major types, ionotropic and metabotropic glutamate receptors.

Ionotropic glutamate receptors (iGluRs), which mediate fast synaptic responses via ion fluxes, are further subdivided into three main groups characterised by their preferential agonists N-methyl-D-aspartate (NMDA), kainate and (S)-a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA). The work of the group combines chemistry and pharmacology. We have synthesized and pharmacologically characterised a range of selective agonists and/or antagonists for each of these receptors by means of which the synaptic receptors in various brain and spinal cord pathways can be identified ...

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Selected publications

• Alushin, G, Jane, D & Mayer, M, 2011, ‘Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists’. Neuropharmacology, vol 60., pp. 126 - 134
• Lamy, C, Goodchild, S, Weatherall, K, Jane, D, Liégeois, J-F, Seutin, V & Marrion, N, 2010, ‘Allosteric block of KCa2 channels by apamin’. Journal of Biological Chemistry, vol 285., pp. 27067 - 27077

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Recent publications

• Sapkota, K, Dore, K, Tang, K, Irvine, M, Fang, G, Burnell, ES, Malinow, R, Jane, DE & Monaghan, DT, 2019, ‘The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators’. Biochemical Pharmacology, vol 159., pp. 140-153
• Irvine, MW, Fang, G, Sapkota, K, Burnell, ES, Volianskis, A, Costa, BM, Culley, G, Collingridge, GL, Monaghan, DT & Jane, DE, 2019, ‘Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid’. European Journal of Medicinal Chemistry, vol 164., pp. 471-498

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View complete publications list in the University of Bristol publications system