Browse/search for people

Publication - Professor Tom Gaunt

    Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis

    Citation

    Hatzikotoulas, K, Tachmazidou, I, Southam, L, Esparza-Gordillo, J, Haberland, V, Zheng, J, Johnson, T, Koprulu, M, Zengini, E, Steinberg, J, Wilkinson, J, Bhatnagar, S, Hoffman, JD, Buchan, N, Suveges, D, Yerges-Armstrong, LM, Smith, GD, Gaunt, T, Scott, R, McCarthy, LC & Zeggini, E, 2019, ‘Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis’.

    Abstract

    Purpose: Osteoarthritis (OA) is the most prevalent musculoskeletal disease and a leading cause of disability worldwide with huge public health burden. The pathogenesis of OA is complex with multiple environmental and genetic factors implicated in the disease aetiology and progression. The heritability of OA is∼ 50% and previous genetic studies have identified 34 loci in total. Here, we conduct the largest genome-wide association study for OA to date to better understand the genetic architecture of the disease and support the development of disease-modifying therapies.

    Full details in the University publications repository