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Publication - Professor Helen Lambert

    Pathways to optimising antibiotic use in rural China identifying key determinants in community and clinical settings, a mixed methods study protocol.

    identifying key determinants in community and clinical settings, a mixed methods study protocol

    Citation

    Zhao, L, Kwiatkowska, R, Chai, J, Cabral, C, Chen, M, Bowker, K, Coope, C, Shen, J, Shen, X, Cheng, J, Feng, R, Kadetz, P, MacGowan, A, Oliver, I, Hickman, M, Wang, D & Lambert, H, 2019, ‘Pathways to optimising antibiotic use in rural China identifying key determinants in community and clinical settings, a mixed methods study protocol.: identifying key determinants in community and clinical settings, a mixed methods study protocol’. BMJ Open, vol 9 .

    Abstract

    Introduction: This study aims to investigate patterns
    of antibiotic treatment-seeking, describe current levels
    of and drivers for antibiotic use for common infections
    (respiratory tract and urinary tract infections) and test the
    feasibility of determining the prevalence and epidemiology
    of antimicrobial resistance (AMR) in rural areas of Anhui
    province, in order to identify potential interventions to
    promote antibiotic stewardship and reduce the burden of
    AMR in China.

    Methods and analysis: We will conduct direct
    observations, structured and semistructured interviews
    in retail pharmacies, village clinics and township health
    centres to investigate treatment-seeking and antibiotic
    use. Clinical isolates from 1550 sputum, throat swab
    and urine samples taken from consenting patients at
    village and township health centres will be analysed
    to identify bacterial pathogens and ascertain antibiotic
    susceptibilities. Healthcare records will be surveyed for a
    subsample of those recruited to the study to assess their
    completeness and accuracy.

    Ethics and dissemination: The full research protocol
    has been reviewed and approved by the Biomedical
    Ethics Committee of Anhui Medical University (reference
    number: 20170271). Participation of patients and doctors
    is voluntary and written informed consent is sought
    from all participants. Findings from the study will be
    disseminated through academic routes including peerreviewed publications and conference presentations, via
    tailored research summaries for health professionals,
    health service managers and policymakers and through
    an end of project impact workshop with local and regional
    stakeholders to identify key messages and priorities for
    action

    Full details in the University publications repository