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Dr Matthew Suderman

Dr Matthew Suderman

Dr Matthew Suderman
PhD

Lecturer in Epigenetic Epidemiology

Area of research

Encoding of early life exposure in DNA methylation

Office BS10
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

Tel. +44 (0) 1173310090

Research summary

Certain early life exposures such as malnutrition and abuse are known to affect health outcomes later in life. However, these relationships are highly variable, dependent on many factors including the unique genetics and environments of each individual. Furthermore, recollections of life history can be extremely inaccurate. Consequently, it can be difficult to identify high-risk individuals, to recommend effective treatments or to assess treatment effectiveness in a timely manner. Recent studies have shown that many exposures are encoded in the methylation levels of blood DNA including cigaratte smoke, age, trauma, diet, stress and socio-economic position. My goal is to characterize the ...

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Biography

In 2005 I received a PhD in Computer Science at McGill University.  My thesis investigated methods for automatically drawing networks on 2-dimensional surfaces. Hoping to apply these methods to biological data, I signed up for postdoctoral research in bioinformatics under the supervision of Michael Hallett (bioinformatics) and later Moshe Szyf (epigenetics). There my focus turned from networks to epigenetics. For the next several years I analyzed  genome-wide DNA methylation and transcriptional profiles from a variety of tissues and organisms for associations with various exposures and disease states. These analyses suggested that blood DNA methylation profiles may be used to piece ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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