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Dr Lavinia Paternoster

Dr Lavinia Paternoster

Dr Lavinia Paternoster
BSc, MSc(Edin), PhD

Research Fellow

Area of research

Genetic Epidemiology of Complex Traits

Office Room OS2
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310135

Summary

I work primarily on genome-wide association studies within the Avon Longitudinal Study of Parents and Children (ALSPAC) and carrying out large-scale, multi-centre genome-wide meta-analyses. Phenotypes of interest include atopic dermatitis (eczema), pQCT measures of bone traits and facial characteristics and measures.

I also work on the Genetics of Obesity in Young Adults (GOYA) study, which aims to identify BMI variants using an extreme sample selection strategy in the Danish population.

Recently awarded an MRC Population Health Fellowship, I have four years funding to research 'The Genetic Epidemiology of Atopic Dermatitis'. This program of research will involve genome-wide association analysis, meta-analysis, analysis of rare variants from sequencing data, investigation of parent-of-origin effects and 'gene by gene' and 'gene by envoronment' interactions.




Activities / Findings

Three risk loci for atopic dermatitis identified in a large-scale genome-wide association meta-analysis (Published, Nature Genetics, Dec 2011)

Teaching

1st year Medicine - Clinical Epidemiology tutor

Postgraduate departmental short-course tutor - Basic Genetics and Genomics; Genetic Association Studies; Introduction to Statistics

Keywords

  • Genetic Epidemiology
  • Complex trait genetics
  • Genome-wide association studies

Skills

  • Atopic dermatitis
  • 3D Facial morphology
  • bone density (pQCT)
  • Obesity
  • Growth

Memberships

Organisations

School of Social and Community Medicine

Recent publications

  • Paternoster, L, Lorentzon, M, Lehtimäki, T, Eriksson, J, Kähönen, M, Raitakari, O, Laaksonen, M, Sievänen, H, Viikari, J, Lyytikäinen, L-P, Mellström, D, Karlsson, M, Ljunggren, O, Grundberg, E, Kemp, JP, Sayers, A, Nethander, M, Evans, DM, Vandenput, L, Tobias, JH & Ohlsson, C 2013, ‘Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure’. PLoS Genet, vol 9., pp. e1003247
  • Northstone, K, Guggenheim, JA, Howe, LD, Tilling, KM, Paternoster, L, Kemp, J, McMahon, G & Williams, C 2013, ‘Body Stature Growth Trajectories during Childhood and the Development of Myopia’. Ophthalmology, vol ePub ahead of print.
  • Howe, LD, Parmar, PG, Paternoster, L, Warrington, NM, Kemp, JP, Briollais, L, Newnham, JP, Timpson, NJ, Smith, GD, Ring, SM, Evans, DM, Tilling, K, Pennell, CE, Beilin, LJ, Palmer, LJ & Lawlor, DA 2013, ‘Genetic Influences on Trajectories of Systolic Blood Pressure Across Childhood and Adolescence’. Circulation: Cardiovascular Genetics, vol 6., pp. 608-614
  • Valk, RJPvd, Duijts, L, Timpson, NJ, Salam, MT, Standl, M, Curtin, JA, Genuneit, J, Kerhof, M, Kreiner-Møller, E, Cáceres, A, Gref, A, Liang, LL, Taal, HR, Bouzigon, E, Demenais, F, Nadif, R, Ober, C, Thompson, EE, Estrada, K, Hofman, A, Uitterlinden, AG, Duijn, Cv, Rivadeneira, F, Li, X, Eckel, SP, Berhane, K, Gauderman, WJ, Granell, R, Evans, DM, St Pourcain, B, McArdle, W, Kemp, JP, Smith, GD, Tiesler, CMT, Flexeder, C, Simpson, A, Murray, CS, Fuchs, O, Postma, DS, Bønnelykke, K, Torrent, M, Andersson, M, Sleiman, P, Hakonarson, H, Cookson, WO, Moffatt, MF, Paternoster, L, Melén, E, Sunyer, J, Bisgaard, H, Koppelman, GH, Ege, M, Custovic, A, Heinrich, J, Gilliland, FD, Henderson, AJ, Jaddoe, VWV, Jongste, JCd & 2013, ‘Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants’. The Journal of Allergy and Clinical Immunology.
  • Evans, DM, Brion, MJA, Paternoster, L, Kemp, JP, McMahon, G, Munafò, M, Whitfield, JB, Medland, SE, Montgomery, GW, Timpson, NJ, St Pourcain, B, Lawlor, DA, Martin, NG, Dehghan, A, Hirschhorn, J, Smith, GD & 2013, ‘Mining the human phenome using allelic scores that index biological intermediates’. PLoS Genet, vol 9., pp. e1003919
  • Fatemifar, G, Hoggart, C, Paternoster, L, Kemp, JP, Prokopenko, I, Horikoshi, M, Wright, V, Tobias, JH, Richmond, S, Zhurov, A, Toma, A, Pouta, A, Taanila, A, Sipila, K, Lahdesmaki, R, Pillas, D, Geller, F, Feenstra, B, Melbye, M, Nohr, E, Ring, S, St Porcain, B, Timpson, N, Smith, GD, Jarvelin, M & Evans, D 2013, ‘Genome-Wide Association Study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances’. Human Molecular Genetics, vol 22., pp. 3807-17
  • Berndt, SI, Gustafsson, S, Mägi, R, Ganna, A, Wheeler, E, Feitosa, MF, Justice, AE, Monda, KL, Croteau-Chonka, DC, Day, FR, Esko, T, Fall, T, Ferreira, T, Gentilini, D, Jackson, AU, Luan, J, Randall, JC, Vedantam, S, Willer, CJ, Winkler, TW, Wood, AR, Workalemahu, T, Hu, Y-J, Lee, SH, Liang, L, Lin, D-Y, Min, JL, Neale, BM, Thorleifsson, G, Yang, J, Albrecht, E, Amin, N, Bragg-Gresham, JL, Cadby, G, Heijer, Md, Eklund, N, Fischer, K, Goel, A, Hottenga, J-J, Huffman, JE, Jarick, I, Johansson, A, Johnson, T, Kanoni, S, Kleber, ME, König, IR, Kristiansson, K, Kutalik, Z, Lamina, C, Lecoeur, C, Li, G, Mangino, M, McArdle, WL, Medina-Gomez, C, Müller-Nurasyid, M, Ngwa, JS, Nolte, IM, Paternoster, L, Pechlivanis, S, Perola, M, Peters, MJ, Preuss, M, Rose, LM, Shi, J, Shungin, D, Smith, AV, Strawbridge, RJ, Surakka, I, Teumer, A, Trip, MD, Tyrer, J, Van Vliet-Ostaptchouk, JV, Vandenput, L, Waite, LL, Zhao, JH, Absher, D, Asselbergs, FW, Atalay, M, Attwood, AP, Balmforth, AJ, Basart, H, Beilby, J, Bonnycastle, LL, Brambilla, P, Bruinenberg, M, Campbell, H, Chasman, DI, Chines, PS, Collins, FS, Connell, JM, Cookson, WO, Faire, Ud, Vegt, Fd, Dei, M, Dimitriou, M, Edkins, S, Estrada, K, Evans, DM, Farrall, M, Ferrario, MM, Ferrières, J, Franke, L, Frau, F, Gejman, PV, Grallert, H, Grönberg, H, Gudnason, V, Hall, AS, Hall, P, Hartikainen, A-L, Hayward, C, Heard-Costa, NL, Heath, AC, Hebebrand, J, Homuth, G, Hu, FB, Hunt, SE, Hyppönen, E, Iribarren, C, Jacobs, KB, Jansson, J-O, Jula, A, Kähönen, M, Kathiresan, S, Kee, F, Khaw, K-T, Kivimäki, M, Koenig, W, Kraja, AT, Kumari, M, Kuulasmaa, K, Kuusisto, J, Laitinen, JH, Lakka, TA, Langenberg, C, Launer, LJ, Lind, L, Lindström, J, Liu, J, Liuzzi, A, Lokki, M-L, Lorentzon, M, Madden, PA, Magnusson, PK, Manunta, P, Marek, D, März, W, Leach, IM, McKnight, B, Medland, SE, Mihailov, E, Milani, L, Montgomery, GW, Mooser, V, Mühleisen, TW, Munroe, PB, Musk, AW, Narisu, N, Navis, G, Nicholson, G, Nohr, EA, Ong, KK, Oostra, BA, Palmer, CNA, Palotie, A, Peden, JF, Pedersen, N, Peters, A, Polasek, O, Pouta, A, Pramstaller, PP, Prokopenko, I, Pütter, C, Radhakrishnan, A, Raitakari, O, Rendon, A, Rivadeneira, F, Rudan, I, Saaristo, TE, Sambrook, JG, Sanders, AR, Sanna, S, Saramies, J, Schipf, S, Schreiber, S, Schunkert, H, Shin, S-Y, Signorini, S, Sinisalo, J, Skrobek, B, Soranzo, N, Stančáková, A, Stark, K, Stephens, JC, Stirrups, K, Stolk, RP, Stumvoll, M, Swift, AJ, Theodoraki, EV, Thorand, B, Tregouet, D-A, Tremoli, E, Klauw, MMVd, Meurs, JBJv, Vermeulen, SH, Viikari, J, Virtamo, J, Vitart, V, Waeber, G, Wang, Z, Widén, E, Wild, SH, Willemsen, G, Winkelmann, BR, Witteman, JCM, Wolffenbuttel, BHR, Wong, A, Wright, AF, Zillikens, MC, Amouyel, P, Boehm, BO, Boerwinkle, E, Boomsma, DI, Caulfield, MJ, Chanock, SJ, Cupples, LA, Cusi, D, Dedoussis, GV, Erdmann, J, Eriksson, JG, Franks, PW, Froguel, P, Gieger, C, Gyllensten, U & 2013, ‘Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture’. NAT GENET.
  • Paternoster, L, Standl, M, Chen, C-M, Ramasamy, A, Bønnelykke, K, Duijts, L, Ferreira, MA, Alves, AC, Thyssen, JP, Albrecht, E, Baurecht, H, Feenstra, B, Sleiman, PMA, Hysi, P, Warrington, NM, Curjuric, I, Myhre, R, Curtin, JA, Groen-Blokhuis, MM, Kerkhof, M, Sääf, A, Franke, A, Ellinghaus, D, Fölster-Holst, R, Dermitzakis, E, Montgomery, SB, Prokisch, H, Heim, K, Hartikainen, A-L, Pouta, A, Pekkanen, J, Blakemore, AIF, Buxton, JL, Kaakinen, M, Duffy, DL, Madden, PA, Heath, AC, Montgomery, GW, Thompson, PJ, Matheson, MC, Le Souëf, P, St Pourcain, B, Smith, GD, Henderson, J, Kemp, JP, Timpson, NJ, Deloukas, P, Ring, SM, Wichmann, H-E, Müller-Nurasyid, M, Novak, N, Klopp, N, Rodríguez, E, McArdle, W, Linneberg, A, Menné, T, Nohr, EA, Hofman, A, Uitterlinden, AG, Duijn, CMv, Rivadeneira, F, Jongste, JCd, Valk, RJPvd, Wjst, M, Jogi, R, Geller, F, Boyd, HA, Murray, JC, Kim, C, Mentch, F, March, M, Mangino, M, Spector, TD, Bataille, V, Pennell, CE, Holt, PG, Sly, P, Tiesler, CMT, Thiering, E, Illig, T, Imboden, M, Nystad, W, Simpson, A, Hottenga, J-J, Postma, D, Koppelman, GH, Smit, HA, Söderhäll, C, Chawes, B, Kreiner-Møller, E, Bisgaard, H, Melén, E, Boomsma, DI, Custovic, A, Jacobsson, B, Probst-Hensch, NM, Palmer, LJ, Glass, D, Hakonarson, H, Melbye, M, Jarvis, DL, Jaddoe, VWV, Gieger, C, Strachan, DP, Martin, NG, Jarvelin, M-R, Heinrich, J, Evans, DM, Weidinger, S, & 2012, ‘Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis’. Nature Genetics, vol 44., pp. 187-192
  • Paternoster, L, Zhurov, A, Toma, A, Kemp, JP, St. Pourcain, MUB, Timpson, N, McMahon, G, McArdle, W, Ring, S, Smith, GD, Richmond, S & Evans, D 2012, ‘Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position’. The American Journal of Human Genetics, vol 90(3)., pp. 478 - 485
  • Tyrrell, J, Huikari, V, Christie, JT, Cavadino, A, Bakker, R, Brion, M-J, Geller, F, Paternoster, L, Myhre, R, Potter, C, Johnson, PCD, Ebrahim, S, Feenstra, B, Hartikainen, A-L, Hattersley, AT, Hofman, A, Kaakinen, M, Lowe, LP, Magnus, P, McConnachie, A, Melbye, M, Ng, JWY, Nohr, EA, Power, C, Ring, SM, Sebert, SP, Sengpiel, V, Taal, HR, Watt, GCM, Sattar, N, Relton, CL, Jacobsson, B, Frayling, TM, Srensen, TIA, Murray, JC, Lawlor, DA, Pennell, CE, Jaddoe, VWV, Hypponen, E, Lowe, WL, Jarvelin, M-R, Smith, GD, Freathy, RM & 2012, ‘Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5CHRNA3CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight’. Human Molecular Genetics, vol 21., pp. 5344-5358

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