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Dr Lavinia Paternoster

Dr Lavinia Paternoster

Dr Lavinia Paternoster
BSc, MSc(Edin), PhD

Research Fellow

Area of research

Genetic Epidemiology of Complex Traits

Office Room OS2
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310135

Summary

I work primarily on genome-wide association studies within the Avon Longitudinal Study of Parents and Children (ALSPAC) and carrying out large-scale, multi-centre genome-wide meta-analyses. Phenotypes of interest include atopic dermatitis (eczema), pQCT measures of bone traits and facial characteristics and measures.

I also work on the Genetics of Obesity in Young Adults (GOYA) study, which aims to identify BMI variants using an extreme sample selection strategy in the Danish population.

Recently awarded an MRC Population Health Fellowship, I have four years funding to research 'The Genetic Epidemiology of Atopic Dermatitis'. This program of research will involve genome-wide association analysis, meta-analysis, analysis of rare variants from sequencing data, investigation of parent-of-origin effects and 'gene by gene' and 'gene by envoronment' interactions.




Activities / Findings

Three risk loci for atopic dermatitis identified in a large-scale genome-wide association meta-analysis (Published, Nature Genetics, Dec 2011)

Teaching

1st year Medicine - Clinical Epidemiology tutor

Postgraduate departmental short-course tutor - Basic Genetics and Genomics; Genetic Association Studies; Introduction to Statistics

Keywords

  • Genetic Epidemiology
  • Complex trait genetics
  • Genome-wide association studies

Skills

  • Atopic dermatitis
  • 3D Facial morphology
  • bone density (pQCT)
  • Obesity
  • Growth

Memberships

Organisations

School of Social and Community Medicine

Selected publications

  • Paternoster, L, Standl, M, Chen, C-M, Ramasamy, A, Bønnelykke, K, Duijts, L, Ferreira, MA, Alves, AC, Thyssen, JP, Albrecht, E, Baurecht, H, Feenstra, B, Sleiman, PMA, Hysi, P, Warrington, NM, Curjuric, I, Myhre, R, Curtin, JA, Groen-Blokhuis, MM, Kerkhof, M, Sääf, A, Franke, A, Ellinghaus, D, Fölster-Holst, R, Dermitzakis, E, Montgomery, SB, Prokisch, H, Heim, K, Hartikainen, A-L, Pouta, A, Pekkanen, J, Blakemore, AIF, Buxton, JL, Kaakinen, M, Duffy, DL, Madden, PA, Heath, AC, Montgomery, GW, Thompson, PJ, Matheson, MC, Le Souëf, P, St Pourcain, B, Smith, GD, Henderson, J, Kemp, JP, Timpson, NJ, Deloukas, P, Ring, SM, Wichmann, H-E, Müller-Nurasyid, M, Novak, N, Klopp, N, Rodríguez, E, McArdle, W, Linneberg, A, Menné, T, Nohr, EA, Hofman, A, Uitterlinden, AG, Duijn, CMv, Rivadeneira, F, Jongste, JCd, Valk, RJPvd, Wjst, M, Jogi, R, Geller, F, Boyd, HA, Murray, JC, Kim, C, Mentch, F, March, M, Mangino, M, Spector, TD, Bataille, V, Pennell, CE, Holt, PG, Sly, P, Tiesler, CMT, Thiering, E, Illig, T, Imboden, M, Nystad, W, Simpson, A, Hottenga, J-J, Postma, D, Koppelman, GH, Smit, HA, Söderhäll, C, Chawes, B, Kreiner-Møller, E, Bisgaard, H, Melén, E, Boomsma, DI, Custovic, A, Jacobsson, B, Probst-Hensch, NM, Palmer, LJ, Glass, D, Hakonarson, H, Melbye, M, Jarvis, DL, Jaddoe, VWV, Gieger, C, Strachan, DP, Martin, NG, Jarvelin, M-R, Heinrich, J, Evans, DM, Weidinger, S, & 2012, ‘Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis’. Nature Genetics, vol 44., pp. 187-192
  • Paternoster, L, Zhurov, A, Toma, A, Kemp, JP, St. Pourcain, MUB, Timpson, N, McMahon, G, McArdle, W, Ring, S, Smith, GD, Richmond, S & Evans, D 2012, ‘Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position’. The American Journal of Human Genetics, vol 90(3)., pp. 478 - 485
  • Paternoster, L, Lorentzon, M, Vandenput, L, Karlsson, M, Ljunggren, O, Kindmark, A, Mellstrom, D, Kemp, JP, Jarett, C, Holly, J, Sayers, A, St. Pourcain, MUB, Timpson, N, Deloukas, P, Smith, GD, Ring, S, Evans, D, Tobias, JH & Ohlsson, C 2010, ‘Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone’. PLoS Genetics, vol 6.

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Recent publications

  • Bønnelykke, K, Sleiman, P, Nielsen, K, Kreiner-Møller, E, Mercader, JM, Belgrave, D, Dekker, HTd, Husby, A, Sevelsted, A, Faura-Tellez, G, Mortensen, LJ, Paternoster, L, Flaaten, R, Mølgaard, A, Smart, DE, Thomsen, PF, Rasmussen, MA, Bonàs-Guarch, S, Holst, C, Nohr, EA, Yadav, R, March, ME, Blicher, T, Lackie, PM, Jaddoe, VWV, Simpson, A, Holloway, JW, Duijts, L, Custovic, A, Davies, DE, Torrents, D, Gupta, R, Hollegaard, MV, Hougaard, DM, Hakonarson, H & Bisgaard, H 2014, ‘A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations’. NAT GENET, vol 46., pp. 51-5
  • Taylor, AE, Fluharty, ME, Bjørngaard, JH, Gabrielsen, ME, Skorpen, F, Marioni, RE, Campbell, A, Engmann, J, Mirza, SS, Loukola, A, Laatikainen, T, Partonen, T, Kaakinen, M, Ducci, F, Cavadino, A, Husemoen, LLN, Ahluwalia, TS, Jacobsen, RK, Skaaby, T, Ebstrup, JF, Mortensen, EL, Minica, CC, Vink, JM, Willemsen, G, Marques-Vidal, P, Dale, CE, Amuzu, A, Lennon, LT, Lahti, J, Palotie, A, Räikkönen, K, Wong, A, Paternoster, L, Wong, AP, Horwood, LJ, Murphy, M, Johnstone, EC, Kennedy, MA, Pausova, Z, Paus, T, Ben-Shlomo, Y, Nohr, EA, Kuh, D, Kivimaki, M, Eriksson, JG, Morris, RW, Casas, JP, Preisig, M, Boomsma, DI, Linneberg, A, Power, C, Hyppönen, E, Veijola, J, Jarvelin, M-R, Korhonen, T, Tiemeier, H, Kumari, M, Porteous, DJ, Hayward, C, Romundstad, PR, Smith, GD & Munafò, MR 2014, ‘Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium’. BMJ Open, vol 4., pp. e006141
  • Vimaleswaran, KS, Cavadino, A, Berry, DJ, Jorde, R, Dieffenbach, AK, Lu, C, Alves, AC, Heerspink, HJL, Tikkanen, E, Eriksson, J, Wong, A, Mangino, M, Jablonski, KA, Nolte, IM, Houston, DK, Ahluwalia, TS, Most, PJvd, Pasko, D, Zgaga, L, Thiering, E, Vitart, V, Fraser, RM, Huffman, JE, Boer, RAd, Schöttker, B, Saum, K-U, McCarthy, MI, Dupuis, J, Herzig, K-H, Sebert, S, Pouta, A, Laitinen, J, Kleber, ME, Navis, G, Lorentzon, M, Jameson, K, Arden, N, Cooper, JA, Acharya, J, Hardy, R, Raitakari, O, Ripatti, S, Billings, LK, Lahti, J, Osmond, C, Penninx, BW, Rejnmark, L, Lohman, KK, Paternoster, L, Stolk, RP, Hernandez, DG, Byberg, L, Hagström, E, Melhus, H, Ingelsson, E, Mellström, D, Ljunggren, O, Tzoulaki, I, McLachlan, S, Theodoratou, E, Tiesler, CMT, Jula, A, Navarro, P, Wright, AF, Polasek, O, Wilson, JF, Rudan, I, Salomaa, V, Heinrich, J, Campbell, H, Price, JF, Karlsson, M, Lind, L, Michaëlsson, K, Bandinelli, S, Frayling, TM, Hartman, CA, Sørensen, TIA, Kritchevsky, SB, Langdahl, BL, Eriksson, JG, Florez, JC, Spector, TD, Lehtimäki, T, Kuh, D, Humphries, SE, Cooper, C, Ohlsson, C, März, W, Borst, MHd, Kumari, M, Kivimaki, M, Wang, TJ, Power, C, Brenner, H, Grimnes, G, Harst, Pvd, Snieder, H, Hingorani, AD, Pilz, S, Whittaker, JC, Järvelin, M-R, Hyppönen, E & 2014, ‘Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study’. The lancet. Diabetes & endocrinology.
  • Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, KL, Tan, Q, Kamatani, Y, Bennet, AM, Tamm, R, Trompet, S, Guðbjartsson, DF, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, HJ, Crocco, P, Akker, EBvd, Böhringer, S, Helmer, Q, Nelson, CP, Saunders, GI, Alver, M, Andersen-Ranberg, K, Breen, ME, Breggen, Rvd, Caliebe, A, Capri, M, Cevenini, E, Collerton, JC, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, Geus, EJCd, Harrow, J, Heemst, Dv, Heijmans, BT, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, PV, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, SE, Mihailov, E, Montesanto, A, Mooijaart, SP, Murphy, A, Nohr, EA, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, OA, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, DJ, Tiemeier, H, Uitterlinden, AG, Westendorp, RGJ, Willemsen, G, Samani, NJ, Galan, P, Sørensen, TIA, Boomsma, DI, Jukema, JW, Rea, IM, Passarino, G, Craen, AJMd, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, TBL, Duijn, CMv, Franceschi, C, Houwing-Duistermaat, JJ & Slagboom, PE 2014, ‘Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age’. Human Molecular Genetics.
  • Sallis, H, Steer, C, Paternoster, L, Smith, GD & Evans, J 2014, ‘Perinatal depression and omega-3 fatty acids: A Mendelian randomisation study’. Journal of Affective Disorders, vol 166., pp. 124-31
  • Warrington, NM, Tilling, K, Howe, LD, Paternoster, L, Pennell, CE, Wu, YY & Briollais, L 2014, ‘Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies’. Statistical Applications in Genetics and Molecular Biology.
  • Kemp, JP, Sayers, A, Paternoster, L, Evans, DM, Deere, K, St Pourcain, B, Timpson, NJ, Ring, SM, Lorentzon, M, Lehtimaki, T, Eriksson, J, Kahonen, M, Raitakari, O, Laaksonen, M, Sievanen, H, Viikari, J, Lyytikainen, L-P, Smith, GD, Fraser, WD, Vandenput, L, Ohlsson, C & Tobias, JH 2014, ‘Does bone resorption stimulate periosteal expansion ? A cross sectional analysis of Beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT’. Am J Bone Miner Research, vol 29., pp. 1015-1024

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