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Dr Lavinia Paternoster

Dr Lavinia Paternoster

Dr Lavinia Paternoster
BSc, MSc(Edin), PhD

Research Fellow

Area of research

Genetic Epidemiology of Complex Traits

Office Room BS9
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310135

Summary

I work primarily on genome-wide association studies within the Avon Longitudinal Study of Parents and Children (ALSPAC) and carrying out large-scale, multi-centre genome-wide meta-analyses. Phenotypes of interest include atopic dermatitis (eczema), pQCT measures of bone traits and facial characteristics and measures.

I also work on the Genetics of Obesity in Young Adults (GOYA) study, which aims to identify BMI variants using an extreme sample selection strategy in the Danish population.

Recently awarded an MRC Population Health Fellowship, I have four years funding to research 'The Genetic Epidemiology of Atopic Dermatitis'. This program of research will involve genome-wide association analysis, meta-analysis, analysis of rare variants from sequencing data, investigation of parent-of-origin effects and 'gene by gene' and 'gene by envoronment' interactions.




Activities / Findings

Three risk loci for atopic dermatitis identified in a large-scale genome-wide association meta-analysis (Published, Nature Genetics, Dec 2011)

Teaching

1st year Medicine - Clinical Epidemiology tutor

Postgraduate departmental short-course tutor - Basic Genetics and Genomics; Genetic Association Studies; Introduction to Statistics

Keywords

  • Genetic Epidemiology
  • Complex trait genetics
  • Genome-wide association studies

Skills

  • Atopic dermatitis
  • 3D Facial morphology
  • bone density (pQCT)
  • Obesity
  • Growth

Memberships

Organisations

School of Social and Community Medicine

Other sites

Centres, collaborations and units

Selected publications

Read more >

Recent publications

  • Okbay, A, Baselmans, BML, De Neve, J-E, Turley, P, Nivard, MG, Fontana, MA, Meddens, SFW, Linnér, RK, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, Vlaming, Rd, Ahluwalia, TS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V, Geisel, MH, Gonzalez, JR, Haitjema, S, Karlsson, R, Laan, SWvd, Ladwig, K-H, Lahti, J, Lee, SJvd, Lind, PA, Liu, T, Matteson, L, Mihailov, E, Miller, MB, Minica, CC, Nolte, IM, Mook-Kanamori, D, Most, PJvd, Oldmeadow, C, Qian, Y, Raitakari, O & others 2016, ‘Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses’. Nature genetics.
  • Tyrrell, J, Richmond, RC, Palmer, TM, Feenstra, B, Rangarajan, J, Metrusky, S, Cavadino, A, Paternoster, L, Armstrong, LL, De Silva, NMG, Wood, AR, Horikoshi, M, Geller, F, Myhre, R, Bradfield, JP, Kreiner-Møller, E, Huikari, V, Painter, JN, Hottenga, JJ, Allard, C, Berry, DJ, Bouchard, L, Das, S, Evans, DM, Hakonarson, H, Hayes, MG, Heikkinen, J, Hofman, A, Knight, BA, Lind, PA, McCarthy, MI, McMahon, G, Medland, SE, Melbye, M, Morris, AP, Nodzenski, M, Reichetzeder, C, Ring, SM, Sebed, S, Sengpiel, V & others 2016, ‘Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight’. Journal of the American Medical Association, vol 315., pp. 1129-1140
  • Ware, JJ, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, RE, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, AI, Hemani, G, Willemsen, G, Hottenga, JJ, Korhonen, T, Heliövaara, M, Perola, M, Rose, RJ, Paternoster, L, Timpson, N, Wassenaar, CA, Zhu, AZX, Smith, GD, Raitakari, OT, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, BWJH, Salomaa, V, Boomsma, DI, Tyndale, RF, Kaprio, J & Munafò, MR, 2016, ‘Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2’. Scientific Reports, vol 6., pp. 20092
  • Colodro-Conde, L, Cross, SM, Lind, PA, Painter, JN, Gunst, A, Jern, P, Johansson, A, Lund Maegbaek, M, Munk-Olsen, T, Nyholt, DR, Ordoñana, JR, Paternoster, L, Sánchez-Romera, JF, Wright, MJ & Medland, SE, 2015, ‘Cohort Profile: Nausea and vomiting during pregnancy genetics consortium (NVP Genetics Consortium)’. International Journal of Epidemiology.
  • Winkler, TW, Justice, AE, Graff, M, Barata, L, Feitosa, MF, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpeläinen, TO, Lu, Y, Mägi, R, Mihailov, E, Pers, TH, Rüeger, S, Teumer, A, Ehret, GB, Ferreira, T, Heard-Costa, NL, Karjalainen, J, Lagou, V, Mahajan, A, Neinast, MD, Prokopenko, I, Simino, J, Teslovich, TM, Jansen, R, Westra, H-J, White, CC, Absher, D, Ahluwalia, TS, Ahmad, S, Albrecht, E, Alves, AC, Bragg-Gresham, JL, Craen, AJMd, Bis, JC, Bonnefond, A, Boucher, G, Cadby, G & others 2015, ‘The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study’. PLoS Genetics, vol 11.
  • Warrington, NM, Howe, LD, Paternoster, L, Kaakinen, M, Herrala, S, Huikari, V, Wu, YY, Kemp, JP, Timpson, NJ, St Pourcain, B, Smith, GD, Tilling, K, Jarvelin, M-R, Pennell, CE, Evans, DM, Lawlor, DA, Briollais, L & Palmer, LJ, 2015, ‘A genome-wide association study of body mass index across early life and childhood’. International journal of epidemiology, vol 44., pp. 700-712
  • , Min, JL, Timpson, NJ, Smith, GD, Evans, D, Gaunt, T, Kemp, J, Northstone, K, Paternoster, L, Shihab, H, Shin, S-Y, St Pourcain, B, Lawson, D, Day, I, Ring, S, Morris, R & Wain, LV, 2015, ‘The UK10K project identifies rare variants in health and disease’. Nature, vol 526., pp. 82-90

View complete publications list in the University of Bristol publications system

Networks & contacts

  • EArly Genetics and Lifecourse Epidemiology (EAGLE) eczema consortium

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