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Dr Lavinia Paternoster

Dr Lavinia Paternoster

Dr Lavinia Paternoster
BSc, MSc(Edin), PhD

Research Fellow

Area of research

Genetic Epidemiology of Complex Traits

Office Room BS9
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310135

Summary

I work primarily on genome-wide association studies within the Avon Longitudinal Study of Parents and Children (ALSPAC) and carrying out large-scale, multi-centre genome-wide meta-analyses. Phenotypes of interest include atopic dermatitis (eczema), pQCT measures of bone traits and facial characteristics and measures.

I also work on the Genetics of Obesity in Young Adults (GOYA) study, which aims to identify BMI variants using an extreme sample selection strategy in the Danish population.

Recently awarded an MRC Population Health Fellowship, I have four years funding to research 'The Genetic Epidemiology of Atopic Dermatitis'. This program of research will involve genome-wide association analysis, meta-analysis, analysis of rare variants from sequencing data, investigation of parent-of-origin effects and 'gene by gene' and 'gene by envoronment' interactions.




Activities / Findings

Three risk loci for atopic dermatitis identified in a large-scale genome-wide association meta-analysis (Published, Nature Genetics, Dec 2011)

Teaching

1st year Medicine - Clinical Epidemiology tutor

Postgraduate departmental short-course tutor - Basic Genetics and Genomics; Genetic Association Studies; Introduction to Statistics

Keywords

  • Genetic Epidemiology
  • Complex trait genetics
  • Genome-wide association studies

Skills

  • Atopic dermatitis
  • 3D Facial morphology
  • bone density (pQCT)
  • Obesity
  • Growth

Memberships

Organisations

School of Social and Community Medicine

Other sites

Centres, collaborations and units

Selected publications

  • Paternoster, L, Standl, M, Chen, C-M, Ramasamy, A, Bønnelykke, K, Duijts, L, Ferreira, MA, Alves, AC, Thyssen, JP, Albrecht, E, Baurecht, H, Feenstra, B, Sleiman, PMA, Hysi, P, Warrington, NM, Curjuric, I, Myhre, R, Curtin, JA, Groen-Blokhuis, MM, Kerkhof, M, Sääf, A, Franke, A, Ellinghaus, D, Fölster-Holst, R, Dermitzakis, E, Montgomery, SB, Prokisch, H, Heim, K, Hartikainen, A-L, Pouta, A, Pekkanen, J, Blakemore, AIF, Buxton, JL, Kaakinen, M, Duffy, DL, Madden, PA, Heath, AC, Montgomery, GW, Thompson, PJ, Matheson, MC, Le Souëf, P, St Pourcain, B, Smith, GD, Henderson, J, Kemp, JP, Timpson, NJ, Deloukas, P, Ring, SM, Wichmann, H-E, Müller-Nurasyid, M, Novak, N, Klopp, N, Rodríguez, E, McArdle, W, Linneberg, A, Menné, T, Nohr, EA, Hofman, A, Uitterlinden, AG, Duijn, CMv, Rivadeneira, F, Jongste, JCd, Valk, RJPvd, Wjst, M, Jogi, R, Geller, F, Boyd, HA, Murray, JC, Kim, C, Mentch, F, March, M, Mangino, M, Spector, TD, Bataille, V, Pennell, CE, Holt, PG, Sly, P, Tiesler, CMT, Thiering, E, Illig, T, Imboden, M, Nystad, W, Simpson, A, Hottenga, J-J, Postma, D, Koppelman, GH, Smit, HA, Söderhäll, C, Chawes, B, Kreiner-Møller, E, Bisgaard, H, Melén, E, Boomsma, DI, Custovic, A, Jacobsson, B, Probst-Hensch, NM, Palmer, LJ, Glass, D, Hakonarson, H, Melbye, M, Jarvis, DL, Jaddoe, VWV, Gieger, C, Strachan, DP, Martin, NG, Jarvelin, M-R, Heinrich, J, Evans, DM, Weidinger, S, & 2012, ‘Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis’. Nature Genetics, vol 44., pp. 187-192
  • Paternoster, L, Zhurov, A, Toma, A, Kemp, JP, St. Pourcain, MUB, Timpson, N, McMahon, G, McArdle, W, Ring, S, Smith, GD, Richmond, S & Evans, D 2012, ‘Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position’. The American Journal of Human Genetics, vol 90(3)., pp. 478 - 485
  • Paternoster, L, Lorentzon, M, Vandenput, L, Karlsson, M, Ljunggren, O, Kindmark, A, Mellstrom, D, Kemp, JP, Jarett, C, Holly, J, Sayers, A, St. Pourcain, MUB, Timpson, N, Deloukas, P, Smith, GD, Ring, S, Evans, D, Tobias, JH & Ohlsson, C 2010, ‘Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone’. PLoS Genetics, vol 6.

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Recent publications

  • Morris, R, Taylor, A, Fluharty, M, Bjørngaard, JH, Åsvold, B, Gabrielsen, ME, Campbell, A, Marioni, RE, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, LLN, Skaaby, T, Ahluwalia, T, Treur, JL, Willemsen, G, Dale, C, Wannamethee, SG, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, LJ, Fergusson, DM, Kennedy, MA, Nohr, EA, Christiansen, L, Kyvik, KO, Kuh, D, Watt, G, Eriksson, JG, Whincup, PH, Vink, JM, Boomsma, DI, Smith, GD, Lawlor, D, Linneberg, A, Ford, I, Jukema, JW, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, BH, Hayward, C, Romundstad, PR, Sørensen, TIA, Munafo, M & Sattar, N 2015, ‘Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium’. BMJ Open, vol 5.
  • Warrington, NM, Howe, LD, Paternoster, L, Kaakinen, M, Herrala, S, Huikari, V, Wu, YY, Kemp, JP, Timpson, NJ, St Pourcain, B, Smith, GD, Tilling, K, Jarvelin, M-R, Pennell, CE, Evans, DM, Lawlor, DA, Briollais, L, Palmer, LJ & Sterne, J 2015, ‘A genome-wide association study of body mass index across early life and childhood’. International journal of epidemiology.
  • Taylor, AE, Fluharty, ME, Bjørngaard, JH, Gabrielsen, ME, Skorpen, F, Marioni, RE, Campbell, A, Engmann, J, Mirza, SS, Loukola, A, Laatikainen, T, Partonen, T, Kaakinen, M, Ducci, F, Cavadino, A, Husemoen, LLN, Ahluwalia, TS, Jacobsen, RK, Skaaby, T, Ebstrup, JF, Mortensen, EL, Minica, CC, Vink, JM, Willemsen, G, Marques-Vidal, P, Dale, CE, Amuzu, A, Lennon, LT, Lahti, J, Palotie, A, Räikkönen, K, Wong, A, Paternoster, L, Wong, AP, Horwood, LJ, Murphy, M, Johnstone, EC, Kennedy, MA, Pausova, Z, Paus, T, Ben-Shlomo, Y, Nohr, EA, Kuh, D, Kivimaki, M, Eriksson, JG, Morris, RW, Casas, JP, Preisig, M, Boomsma, DI, Linneberg, A, Power, C, Hyppönen, E, Veijola, J, Jarvelin, M-R, Korhonen, T, Tiemeier, H, Kumari, M, Porteous, DJ, Hayward, C, Romundstad, PR, Smith, GD & Munafò, MR 2014, ‘Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium’. BMJ Open, vol 4., pp. e006141
  • Taylor, AE, Morris, RW, Fluharty, ME, Bjorngaard, JH, Asvold, BO, Gabrielsen, ME, Campbell, A, Marioni, R, Kumari, M, Hällfors, J, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, LLN, Skaaby, T, Ahluwalia, TS, Treur, JL, Willemsen, G, Dale, C, Wannamethee, SG, Lahti, J, Palotie, A, Räikkönen, K, Kisialiou, A, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, DM, Kennedy, MA, Frayling, T, Nohr, EA, Christiansen, L, Kyvik, KO, Kuh, D, Watt, G, Eriksson, J, Whincup, PH, Vink, JM, Boomsma, DI, Smith, GD, Lawlor, D, Linneberg, A, Ford, I, Jukema, JW, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, BH, Hayward, C, Romundstad, PR, Sørensen, TIA, Munafò, MR & Sattar, N 2014, ‘Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers’. PLoS Genetics, vol 10., pp. e1004799
  • Sallis, H, Steer, C, Paternoster, L, Smith, GD & Evans, J 2014, ‘Perinatal depression and omega-3 fatty acids: A Mendelian randomisation study’. Journal of Affective Disorders, vol 166., pp. 124-31
  • Kemp, JP, Sayers, A, Paternoster, L, Evans, DM, Deere, K, St Pourcain, B, Timpson, NJ, Ring, SM, Lorentzon, M, Lehtimaki, T, Eriksson, J, Kahonen, M, Raitakari, O, Laaksonen, M, Sievanen, H, Viikari, J, Lyytikainen, L-P, Smith, GD, Fraser, WD, Vandenput, L, Ohlsson, C & Tobias, JH 2014, ‘Does bone resorption stimulate periosteal expansion ? A cross sectional analysis of Beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT’. Am J Bone Miner Research, vol 29., pp. 1015-1024
  • Perry, JRB, Day, F, Elks, CE, Sulem, P, Thompson, DJ, Ferreira, T, He, C, Chasman, DI, Esko, T, Thorleifsson, G, Albrecht, E, Ang, WQ, Corre, T, Cousminer, DL, Feenstra, B, Franceschini, N, Ganna, A, Johnson, AD, Kjellqvist, S, Lunetta, KL, McMahon, G, Nolte, IM, Paternoster, L, Porcu, E, Smith, AV, Stolk, L, Teumer, A, Tšernikova, N, Tikkanen, E, Ulivi, S, Wagner, EK, Amin, N, Bierut, LJ, Byrne, EM, Hottenga, J-J, Koller, DL, Mangino, M, Pers, TH, Yerges-Armstrong, LM, Zhao, JH, Andrulis, IL, Anton-Culver, H, Atsma, F, Bandinelli, S, Beckmann, MW, Benitez, J, Blomqvist, C, Bojesen, SE, Bolla, MK, Bonanni, B, Brauch, H, Brenner, H, Buring, JE, Chang-Claude, J, Chanock, S, Chen, J, Chenevix-Trench, G, Collée, JM, Couch, FJ, Couper, D, Coviello, AD, Cox, A, Czene, K, D'adamo, AP, Smith, GD, De Vivo, I, Demerath, EW, Dennis, J, Devilee, P, Dieffenbach, AK, Dunning, AM, Eiriksdottir, G, Eriksson, JG, Fasching, PA, Ferrucci, L, Flesch-Janys, D, Flyger, H, Foroud, T, Franke, L, Garcia, ME, García-Closas, M, Geller, F, Geus, EEJd, Giles, GG, Gudbjartsson, DF, Gudnason, V, Guénel, P, Guo, S, Hall, P, Hamann, U, Haring, R, Hartman, CA, Heath, AC, Hofman, A, Hooning, MJ, Hopper, JL, Hu, FB, Hunter, DJ, Karasik, D, Kiel, DP, Knight, JA, Kosma, V-M, Kutalik, Z, Lai, S, Lambrechts, D, Lindblom, A, Mägi, R, Magnusson, PK, Mannermaa, A, Martin, NG, Masson, G, McArdle, PF, McArdle, WL, Melbye, M, Michailidou, K, Mihailov, E, Milani, L, Milne, RL, Nevanlinna, H, Neven, P, Nohr, EA, Oldehinkel, AJ, Oostra, BA, Palotie, A, Peacock, M, Pedersen, NL, Peterlongo, P, Peto, J, Pharoah, PDP, Postma, DS, Pouta, A, Pylkäs, K, Radice, P, Ring, S, Rivadeneira, F, Robino, A, Rose, LM, Rudolph, A, Salomaa, V, Sanna, S, Schlessinger, D, Schmidt, MK, Southey, MC, Sovio, U, Stampfer, MJ, Stöckl, D, Storniolo, AM, Timpson, NJ, Tyrer, J, Visser, JA, Vollenweider, P, Völzke, H, Waeber, G, Waldenberger, M, Wallaschofski, H, Wang, Q, Willemsen, G, Winqvist, R, Wolffenbuttel, BHR, Wright, MJ, Boomsma, DI, Econs, MJ, Khaw, K-T, Loos, RJF, McCarthy, MI, Montgomery, GW, Rice, JP, Streeten, EA, Thorsteinsdottir, U, Duijn, CMv, Alizadeh, BZ, Bergmann, S, Boerwinkle, E, Boyd, HA, Crisponi, L, Gasparini, P, Gieger, C, Harris, TB, Ingelsson, E, Järvelin, M-R, Kraft, P, Lawlor, D, Metspalu, A, Pennell, CE, Ridker, PM, Snieder, H, Sørensen, TIA, Spector, TD, Strachan, DP, Uitterlinden, AG, Wareham, NJ, Widen, E, Zygmunt, M, Murray, A, Easton, DF, Stefansson, K, Murabito, JM, Ong, KK & 2014, ‘Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche’. Nature, vol 514., pp. 92-7

View complete publications list in the University of Bristol publications system

Networks & contacts

  • EArly Genetics and Lifecourse Epidemiology (EAGLE) eczema consortium

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