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Dr Lavinia Paternoster

Dr Lavinia Paternoster

Dr Lavinia Paternoster
BSc, MSc(Edin.), PhD

Senior Lecturer in Genetic Epidemiology

Area of research

Genetic Epidemiology of Complex Traits

Office BGB
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310135

Summary

I am a Senior Lecturer in Genetic Epidemiology at the MRC Integrative Epidemiology Unit at the University of Bristol. My research is focused on the genetic aetiology of atopic dermatitis and related traits.

I am a leading member of the EAGLE eczema consortium, which brings together studies from around the world with eczema and genetic data in order to conduct large-scale research. Our aim is to identify genetic variants associated with eczema in order to improve understanding of the disease and inform therapeutic development. We have published two large genome-wide association studies for eczema, the largest of which (Paternoster et al., 2015, Nature Genetics) studied 21,000 cases and identified 10 novel risk loci for the disease, bringing the total number of established loci to 31 (24 in Europeans). I am also interested in sub-classes of atopic dermatitis and have worked with latent class analysis to determine longitudinal patterns of the disease throughout childhood and have keen interest in determining genetic risk factors for progression of the disease and response to treatment.

I work with a number of datasets:

- ALSPAC (The Avon Longitudinal Study of Parents and Children)

- UK Biobank

- EAGLE eczema consortium

- GOYA (Genomics of Obese Young Adults)


Methods:

- Genome-wide association studies

- Target identification

- Mendelian Randomization

- Genetics of Progression

Activities / Findings

Ten risk loci for atopic dermatitis identified in a large-scale genome-wide association meta-analysis (Published, Nature Genetics, Dec 2015)

Teaching

Co-ordinator for Genetic Epidemiology short course

Unit lead for Genomic Medicine (iBSc Genomic Medicine)

Keywords

  • Genetic Epidemiology
  • Complex trait genetics
  • Genome-wide association studies

Skills

  • Atopic dermatitis
  • atopic disease

Memberships

Organisations

Bristol Medical School (PHS)

Other sites

Centres, collaborations and units

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • EArly Genetics and Lifecourse Epidemiology (EAGLE) eczema consortium

Courses

Dr Paternoster currently teaches 1 courses:

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