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Dr Kyla Thomas

Dr Kyla Thomas

Dr Kyla Thomas
MBBS(West Indies), MSc (Oxon), MSc Res(Oxon), MFPH, PhD, FFPH

Consultant Senior Lecturer in Public Health Medicine

Area of research

Prescription opioid dependence, Pharmacoepidemiology, Safety of smoking cessation medicines, Mental Health

Office Room 3.12
Canynge Hall,
39 Whatley Road, Bristol BS8 2PS
(See a map)

+44 (0) 1454 864 582
+44 (0) 117 928 7200

Summary

I am a Consultant Senior Lecturer in Public Health with interests in:

- pharmacoepidemiology, in particular psychiatric adverse drug reactions (depression, non-fatal self-harm and suicide) associated with varenicline, a smoking cessation medicine and antidepressants

- use of large primary care databases such as the Clinical Practice Research Datalink (CPRD) for observational research including novel study designs for dealing with confounding by indication such as instrumental variables and case only designs

- substance dependence and addiction (prescription opioid dependence)

- mental health research (suicide and self-harm) and suicide prevention

- trends in suicide in the UK and internationally

Biography

I am currently a Consultant Senior Lecturer in Public Health Medicine based at the University of Bristol and South Gloucestershire Council (60:40 academic:clinical split). I started a National Institute for Health Research (NIHR) Postdoctoral Fellowship in January 2018. Prior to this I was employed as a Consultant in Public Health at South Gloucestershire Council (0.6 FTE) and a Clinical Lecturer in Public Health Medicine at the University of Bristol (0.5 FTE). 

I completed my NIHR Academic Clinical Lectureship in Public Health in October 2016 (50:50 service:academic post).

My three year NIHR Doctoral Research Fellowship (January 2011-December 2013) involved examining the association between specific prescribed drugs (smoking cessation medicines and antidepressants) and psychiatric adverse drug reactions (depression, non-fatal self-harm and suicide) using the Clinical Practice Research Datalink (CPRD), formerly known as the General Practice Research Database (GPRD). I was awarded a PhD with Commendation from the University of Bristol in March 2014.

I am a Fellow of the UK's Faculty of Public Health. In addition, I completed a Certificate in Pharmacoepidemiology and Pharmacovigilance with Distinction at the London School of Hygiene and Tropical Medicine (LSHTM) in 2012. 

I obtained my primary medical degree with Distinction from the University of the West Indies in 2003. Following this, I spent three years at Oxford University on a Commonwealth Caribbean Rhodes Scholarship before completing Foundation training in the Oxford Deanery. I joined the South West Public Health training scheme as an NIHR Academic Clinical Fellow in 2008. 

I am currently an Assistant Editor with the Addiction journal. From October 2017 I work one day a week as Clinical Co-Director/Clinical Director Designate for the NIHR West of England Clinical Research Network (CRN). 

CURRENT GRANTS

-Kyla Thomas (PI)- Prescription opioid analgesics for chronic non-cancer pain. Developing a primary care-based intervention to prevent and reduce opioid dependence. NIHR Postdoctoral Fellowship. Amount £454,000. Awarded Jan 2018 for 60 months.
 
-Kyla Thomas (PI)- How do smoking cessation medicines compare with respect to their neuropsyhciatric safety: a systematic review, network meta-analysis and cost effectiveness analysis. NIHR HTA Evidence Synthesis. Amount £380,000. Awarded Sep 2016 for 26 months.
 
-  Kyla Thomas (PI), Rona Campbell, Matt Hickman, John Macleod, Tony Pickering. Evaluation of Year 1 of the South Gloucestershire Opioid Analgesics Dependency Pilot. CLAHRC West Evaluation of Health Services Theme. Awarded September 2016. 
 
- Kyla Thomas-Use of novel case-only methods to investigate the neuropsychiatric and cardiovascular safety of varenicline in the UK Clinical Practice Research datalink. Academy of Medical Sciences starter grant for clinical lecturers. Amount £30,000 Awarded Jan 2015 until Dec 2018.
 
- Kyla Thomas (PI), David Gunnell, Christabel Owens, Lucy Biddle, Salena Williams, Naomi Salisbury. Engaging patients meaningfully in self harm research: Part I: appropriate outcomes and Part II: engagement. CLAHRC West Public Health Research Theme Awarded Dec 2014.
 

-Neil Davies (PI), Kyla Thomas, Amy Taylor, Gemma Taylor, Frank Windmeijer, Richard Martin, Marcus Munafo. What is the effectiveness of varenicline compared with nicotine replacement therapy for long term smoking cessation and clinically important outcomes such as mortality, myocardial infarction and frequency of service use? Evidence from the Clinical Practice Research Datalink. NIHR HTA Efficient Study Designs and MRC methodology bolt on. Amount £205,942 (and £99,000 for bolt on). Awarded Sep 2015 for 28 months.  

PREVIOUS GRANTS

- Kyla Thomas. The association of prescribed drugs with psychiatric adverse drug reactions. NIHR Doctoral Fellowship. January 2011- December 2013. Amount £250,000.

 -Kyla Thomas. Rhodes Scholarship for the Commonwealth Caribbean. October 2003 - June 2006. Amount £100,000.

 PAST PROJECTS

- suicide trends and epidemiology (NIHR Academic Clinical Fellowship)

- epidemiological investigations into cervical cancer as part of a MSc (Research) in Epidemiology at Oxford University (Rhodes Scholarship)

- methods of gestational age assessment in Karen newborns in Mae Sot, Thailand (dissertation for the MSc in Global health Science/MPH equivalent at Oxford, passed with Distinction- Rhodes Scholarship)

My Google Scholar page can be found here.

Teaching

I am Public Health champion for the Global and Public Health helical theme in the new medical undergraduate curriculum MB21 (launched in Sep 2017).

I was Public Health element lead for Community Oriented Medical Practice (COMP) for 4th year Bristol medical students from 2010-2012 and 2014-2015. I currently teach on this course.  I have previously taught Clinical Epidemiology to first year medical students.

I also participate in revision courses for public health registrars on the South West Public Health training scheme prior to the Part A examination.

Keywords

  • addiction
  • drug safety
  • suicide
  • self-harm

Skills

  • prescription opioid dependence
  • adverse drug reactions
  • mental health

Methodologies

  • quantitative methods including systematic reviews and observational studies using large primary care databases such as the Clinical Practice Research Datalink (CPRD)
  • qualitative methods

Memberships

Organisations

Bristol Medical School (PHS)

Centres, collaborations and units

Selected publications

Read more >

View complete publications list in the University of Bristol publications system

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