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Professor John Henderson
Professor John Henderson
Professor of Paediatric Respiratory Medicine
Area of research
Genetic and environmental origins of asthma and allergy
My research interests are primarily centred on identification of early life factors associated with the development of asthma and allergies in children. I work with the Avon Longitudinal Study of Parents and Children (ALPSAC) cohort, where I have established a programme of respiratory follow up that includes lung function measurements, assessment of allergies and longitudinal infromation on wheezing illnesses and asthma through childhood. Recent work has focused on identifying different phenotypes of asthma in early childhood and investigating differential genetic and environmental influences on their development. The ALSPAC cohort has also made substantial contibutions to international collaborations to conduct genomewide association studies (GWAS) of asthma and allergies; we are currently leading a GWAS of early childhood wheezing phenotypes in collaboration with the The EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium.
I am a Reader in Paediatric Respiratory Medicine. My background is in clinical paediatrics and I have trained in paediatric respiratory medicine, neonatal medicine and paediatric intensive care. My early research career was based around physiology of the respiratory system in children and infants.
For the past decade, my main research interests have been centred on the epidemiology of asthma and allergy in children, working with the Avon Longitudinal Study of Parents & Children (ALSPAC). I also have a major clinical role in the assessment and treatment of children with neuromuscular diseases and have recently developed a research programme in the evaluation of respiratory muscle function in this group of young people.
respiratory medicineclinical paediatricsrespiratory systemchildrenintensive careasthmaallergy
- Wain, LV, Shrine, N, Artigas, MS, Erzurumluoglu, AM, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, AP, Portelli, MA, Hall, RJ, Billington, CK, Rimington, TL, Fenech, AG, John, C, Blake, T, Jackson, VE, Allen, RJ, Prins, BP, Campbell, A, Porteous, DJ, Jarvelin, MR, Wielscher, M, James, AL, Hui, J, Wareham, NJ, Zhao, JH, Wilson, JF, Joshi, PK, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, NM, Karrasch, S, Gieger, C, Deary, IJ, Harris, SE, Marten, J, Rudan, I, Enroth, S & others 2017, Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature Genetics, vol 49., pp. 416-425
- Belgrave, D, Henderson, J, Simpson, A, Buchan, I, Bishop, C & Custovic, A, 2017, Disaggregating Asthma: Big Investigation vs. Big Data. Journal of Allergy and Clinical Immunology, vol 139., pp. 400-407
- Shrine, NRG, Tobin, M, Schurmann, C, Artigas, MS, Hui, J, Lehtimäki, T, Pennell, CE, Ang, QW, Strachan, DP, Homuth, G, Gläser, S, Felix, SB, Evans, D, Henderson, AJW, Granell, R, Palmer, LJ, Hayward, C, , Malarstig, A, Musk, B, James, AL, & Wain, LV, 2016, Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for Forced Vital Capacity. BMC Genetics, vol 17.
- Jago, R, Searle, A, Henderson, J & Turner, K, 2016, Designing a physical activity intervention for children with asthma: A Qualitative study of the views of health care professionals, parents and children with asthma. BMJ Open.
- Kreiner-Moller, E, Waage, J, Standl, M, Brix, S, Pers, TH, Alves, AC, Warrington, NM, Tiesler, CMT, Fuertes, E, Franke, L, Hirschhorn, JN, James, A, Simpson, A, Tung, JY, Koppelman, GH, Postma, DS, Pennell, CE, Jarvelin, M-R, Custovic, A, Timpson, N, Ferreira, MA, Strachan, DP, Henderson, J, Hinds, DA, Bisgaard, H & Bønnelykke, K, 2016, Shared genetic variants suggest common pathways in allergy and autoimmune diseases. Journal of Allergy and Clinical Immunology.
- Granell, R, Henderson, AJ & Sterne, JA, 2016, Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort. Journal of Allergy and Clinical Immunology, vol 138., pp. 1060-1070.e11
- Gallo, V, Holloway, JW, Ring, S, Koppelman, GH, Postma, D, Strachan, DP, Granell, R, De Jongste, J, Jaddoe, VWV, den Dekker, HT, Duijts, L, Henderson, J & Shaheen, SO, 2016, TRPA1 gene polymorphisms and childhood asthma. Pediatric Allergy and Immunology.
- Shaheen, SO, Macdonald-Wallis, C, Lawlor, DA & Henderson, AJ, 2016, Hypertensive disorders of pregnancy, respiratory outcomes and atopy in childhood. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol 47., pp. 156-65
- Kouzouna, A, Gilchrist, F, Ball, V, Kyriacou, T, Henderson, AJW, Pandyan, A & Lenney, W, 2016, A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews.
- Duijts, L, Granell, R, Sterne, JAC & Henderson, AJ, 2016, Childhood wheezing phenotypes influence asthma, lung function and exhaled nitric oxide fraction in adolescence. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol 47., pp. 510-9
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