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Publication - Dr Jenny Ingram

    Script in a Day intervention for individuals who are injecting opioids

    a feasibility randomized control trial


    Beattie, AM, Marques, EMR, Barber, M, Greenwood, RJ, Ingram, JC, Ayres, R, Neale, J, Rees, A, Coleman, B & Hickman, M, 2016, ‘Script in a Day intervention for individuals who are injecting opioids: a feasibility randomized control trial’. Journal of Public Health, vol 38., pp. 712-721


    Background: Opioid substitution treatment (OST) reduces the harm of injecting and opioid dependence. The SCID feasibility trial explored the processes of conducting a randomized control trial (RCT) with people who inject drugs (PWID) in a low-threshold agency. Feasibility of the intervention investigated whether offering PWID immediate access to OST via specialist primary care increased numbers in OST at 3 months, compared with offering advice and case management.

    Methods: Un-blinded RCT was conducted at Bristol Drugs Project needle exchange. A total of 311 individuals were eligible and 100 consented to participate. Trial process outcomes involved exploring OST status at 3 months; secondary outcomes were substance use and health-related quality of life measures.

    Results: Follow-up was 86%. At 3 months, 51% intervention and 47% of control participants were in OST (OR of success of intervention 1.17 (0.54-2.57)). Opioid use reduced by 79 and 73%, respectively (OR of intervention success 1.38 (0.5-3.7)). Physical and mental health improved but there was little differences between groups.

    Conclusions: The feasibility of conducting the trial was a success, but there was insufficient evidence of an effect compared with intensive case management. Further development and evaluation of case management approaches in low-threshold agencies is warranted.

    Full details in the University publications repository