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Publication - Miss Daisy Gaunt

    The Patient-Oriented Eczema Measure in young children

    Responsiveness and minimal clinically important difference

    Citation

    Gaunt, DM, Metcalfe, C & Ridd, M, 2016, ‘The Patient-Oriented Eczema Measure in young children: Responsiveness and minimal clinically important difference’. Allergy, vol 71., pp. 1620-1625

    Abstract

    Background The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomised feasibility study we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema.

    Methods Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor-based methods using PGA as the anchor: the within-patient score change, between-patient score change and sensitivity and specificity method, and two distribution-based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores. 

    Results Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within-patient score change (4.27), the between-patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50). 

    Conclusions The Patient-Oriented Eczema Measure as applied to young children is responsive to change and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future RCTs of treatments for eczema in young children.

    Full details in the University publications repository