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Professor Andrew Dowsey

Professor Andrew Dowsey

Professor Andrew Dowsey
MEng(Lond), PhD

Professor

Chair in Population Health Data Science

Office OF19
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 33 10051

Summary

My research concerns the combination of bioinformatics and biostatistics approaches to integrate disparate data sources for medical and veterinary research. We are experienced with handling modalities including quantitative omics data (transcriptomics, proteomics, metabolomics), medical images (MRI, CT, PET, Ultrasound) and pervasive sensing/biosensing data, together with clinical metadata. I also lead a research programme focussed on new computational methodology for biological mass spectrometry. We are building statistical methodology that operates from sensor readings to biological processes, together with approaches for visualisation and quality control of the raw data and results. For more information please visit my Research Group website.

Current Grants

Sole Investigator, A holistic statistical modelling approach to quantitative discovery proteomics and metabolomics for underpinning integrative systems medicine, MRC Methodology New Investigator Research Grant MR/L011093/1.

Principal Investigator, Bayesian quantitative proteomics, Bilateral NSF/BIO-BBSRC Project Grant BB/M024954/1.

Principal Investigator, Delivering a production platform and atlas for next-generation biomarker discovery, validation and assay development in clinical proteomics, MRC Methodology Project Grant MR/N028457/1.

Co-Principal Investigator, Multi-dimensional visualisation and annotation platform for mass spectrometry, BBSRC Follow on Fund Grant BB/N012534/1.

Co-Investigator, Elucidation of molecular mechanisms underpinning disease initiation and progression in age-related macular degeneration, Fight for Sight Project Grant.

Previous Grants

Sole Investigator, High-throughput differential expression proteomics, EPSRC Overseas Fellowship at the Life Sciences Interface EP/E03988X/1.

Principal Investigator, Unifying metabolome and proteome informatics, BBSRC TRDF2 Grant BB/L018616/1.

Principal Investigator, Streaming 3D visualisation platform for raw and analysed data from proteomics and metabolomics repositories, BBSRC TRDF2 Grant BB/K016733/1.

Principal Investigator, Signal-based image registration and mixed modelling for differential analysis of large scale cross-omics datasets, BBSRC TRDF2 Grant BB/K004158/1. 

Co-Principal Investigator, ProteoFormer - a software toolkit for top-down proteomics, BBSRC TRDF2 Grant BB/L018454/1.

Co-Investigator, Time course of development of diabetic nephropathy and its reversal by copper chelation, MRC Project Grant MRC MR/L010445/1.

Co-Investigator, Molecular dissection of human Alzheimer's Disease, Alzheimer's Research UK Pilot Grant.

Biography

2016 to present, Chair in One Health Bioinformatics and Biostatistics, School of Social & Community Medicine and School of Veterinary Sciences, University of Bristol.

2012 to present, CADET Bioinformatics Research Lead, Centre for Advanced Discovery and Experimental Therapeutics, Institute of Human Development, University of Manchester.

2012 to present, Visiting Academic, The Hamlyn Centre, Institute of Global Health Innovation, Imperial College London.

2015 to 2016, Reader in Biomedical Signal Processing & Informatics, Department of Electrical Engineering & Electronics, University of Liverpool.

2012 to 2015, Lecturer in Bioinformatics, Centre for Advanced Discovery and Experimental Therapeutics, Institute of Human Development, University of Manchester.

2008 to 2011, EPSRC Overseas Fellowship at the Life Sciences Interface, Institute of Biomedical Engineering and Hamlyn Centre, Institute of Global Health Innovation, Imperial College London (also Visiting Fellow at University of Texas MD Anderson Cancer Centre and University College Dublin).

2005 to 2007, Postdoctoral Scientist in Medical Image Analysis for MRI and CT, Royal Society / Wolfson Medical Image Computing Laboratory, Imperial College London.

2001 to 2005, PhD in Image Analysis for Proteomics, Royal Society / Wolfson Medical Image Computing Laboratory, Imperial College London (supervisors Prof. Guang-Zhong Yang and Prof. Mike Dunn).

1997 to 2001, MEng in Computing (Software Engineering), 1st Class Honours, Imperial College London.

Activities / Findings

Please see my Research Group website.

Skills

  • Infectious disease

Methodologies

  • Proteomics
  • Bayesian and MCMC models

Recent publications

View complete publications list in the University of Bristol publications system

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