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Dr Zuner Bortolotto

Synaptic plasticity and epilepsy

Understanding the mechanisms underlying basic functions of the brain, such as synaptic transmission and plasticity. These represent fundamental functions and abilities of the brain that affect its output activities. These also forms the molecular basis of the brain activity which are involved in neurological conditions affecting learning and memory and/or implicated in Alzheimer's disease and epilepsy. We are investigating the roles different receptor systems in the control of synaptic plasticity and epileptiform activity in the hippocampus.

Research keywords

  • Glutamate receptors
  • Synaptic plasticity
  • acetyl choline
  • Epileptic activity
  • LTP
  • LTD

Diseases related to this field of research

  • Epilepsy
  • Alzheimer's desease

Processes and functions relevant to this work

  • Synaptic transmission
  • Learning and memory
  • development
  • behaviour

Equipment relevant to this work

  • Electrophysiology equipment
  • computer systems and analysis programs

Research findings

  • GluK1-containing KARs are important for regulating synaptic facilitation and LTP induction at hippocampal mossy fiber synapses Read more >
  • Activation of mGluRs can induce long-term alterations in synchronised network activity in the absence of chemical synaptic transmission
  • Setting of the mlecular switch is dependent on the activation of mGlu5 receptors Read more >

Collaborations

  • Professor David E Jane
  • Professor Graham Collingridge
  • Professor David Lodge (Eli Lilly)