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Dr Zuner Bortolotto

Dr Zuner Bortolotto

Dr Zuner Bortolotto
Ph.D.(SaoPaulo)

Senior Lecturer

Area of research

Synaptic plasticity and epilepsy

Office G22
School of Physiology, Pharmacology & Neu,
Biomedical Sciences Building, University Walk BS8 1TD
(See a map)

+44 (0) 117 331 1913

Summary

Understanding the mechanisms underlying basic functions of the brain, such as synaptic transmission and plasticity. These represent fundamental functions and abilities of the brain that affect its output activities. These also forms the molecular basis of the brain activity which are involved in neurological conditions affecting learning and memory and/or implicated in Alzheimer's disease and epilepsy. We are investigating the roles different receptor systems in the control of synaptic plasticity and epileptiform activity in the hippocampus.

Activities / Findings

  • GluK1-containing KARs are important for regulating synaptic facilitation and LTP induction at hippocampal mossy fiber synapses Read more >
  • Activation of mGluRs can induce long-term alterations in synchronised network activity in the absence of chemical synaptic transmission
  • Setting of the mlecular switch is dependent on the activation of mGlu5 receptors Read more >

Teaching

  • Neurosciences: Techniques in Neuroscience (Unit organiser plus PBL sessions, lab practical and lectures)
  • Anatomical Sciences: year III - Lectures (Pathophysiology of epilepsy and EEG)
  • BVSc - 2nd Year Vets - Neuroanatomy (Element lecturer)

Keywords

  • Glutamate receptors
  • Synaptic plasticity
  • acetyl choline
  • Epileptic activity
  • LTP
  • LTD

Skills

  • Epilepsy
  • Alzheimer's desease

Processes and functions

  • Synaptic transmission
  • Learning and memory
  • development
  • behaviour

Methodologies

  • Electrophysiological recording techniques
  • whole cell patch clamp

Links

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Professor David E Jane
  • Professor Graham Collingridge
  • Professor David Lodge (Eli Lilly)

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