Professor Paul Martin

Research summary

Embryos heal wounds very rapidly and efficiently and without leaving a scar. They appear to do this using a very similar portfolio of cellular tools to those used by embyos to undergo the natural morphogenetic movements of development. We hope that studying these parallels will help us better understand embryonic tissue movements and also suggest ways in which we might make adult tissues repair more efficiently. Using live confocal imaging of transgenic Drosophila embryos expressing gfp-actin in epithelial tissues we have compared repair of laser-generated epithelial wounds with the paradigm morphogenetic process of dorsal closure and show that remarkably similar ...

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Selected publications

• Matsubayashi, Y, Razzel, W & Martin, P 2011, ‘White wave analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion’. Journal of Cell Science, vol 24 (7)., pp. 1017 - 1021
• Feng, Y, Santoriello, C, Mione, M, Hurlstone, A & Martin, P 2010, ‘Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: Parallels between tumor initiation and wound inflammation’. PLos Biology, vol 8 (12).

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Recent publications

• Feng, Y, Renshaw, S & Martin, PB 2012, ‘Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.’. Current Biology, vol 22., pp. 1253-1259
• Andrews, SN, Ford, DJ & Martin, PB 2012, ‘Knockdown of osteopontin reduces the inflammatory response and subsequent size of postsurgical adhesions in a murine model.’. Am. J. Pathol, vol 181., pp. 1165-1172

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View complete publications list in the University of Bristol publications system