Dr Andy Salmon

Summary

Healthy kidneys are exceptional filters. They keep blood cells and almost all large proteins (like albumin) in the blood, and filter waste products into the urine. In many forms of kidney disease, this filtration becomes inefficient, and large proteins like albumin enter the urine. This damages the kidneys, and is linked to diseases of other blood vessels, e.g. heart attacks. We are working to understand how kidneys keep albumin in the blood, how this process fails in kidney disease, aiming to find new ways to treat kidney diseases by restoring the kidney's normal filtration processes.

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Biography

Andy Salmon trained in clinical medicine at the University of Bristol, graduating in 1998. Junior doctor posts in general medicine in the South West of England, Nottingham and New Zealand were followed by a Wellcome Trust Research Training Fellowship in the Microvascular Research Laboratories in the Department of Physiology in Bristol, leading to a PhD examining intrinsic regulation of glomerular permeability. He undertook a Clinical Lectureship in Nephrology at the Academic Renal Unit in Bristol, alongside Specialist Registrar training in Nephrology. He took up a Medical Research Council and Academy of Medical Sciences-funded Clinician Scientist Fellowship in December 2009, based in the Microvascular Research Laboratories at the University of Bristol, as well as working with Prof janos Peti-Peterdi at the University of Southern California. His research interests centre around regulation of microvascular permeability in systemic and glomerular vessels.

Skills

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Processes and functions

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Methodologies

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Memberships

Organisations

School of Physiology and Pharmacology

Bristol Heart Institute

Microvascular Research Laboratories

Other sites

• Bhi

Research Areas

• Microvasculature

Research Themes

• Cardiovascular Research

Selected publications

• Qiu, Y, Ferguson, J, Oltean, S, Neal, CR, Kaura, A, Bevan, HS, Wood, E, Sage, LM, Lanati, S, Nowak, DG, Salmon, AHJ, Bates, DO & Harper, SJ. ‘Overexpression of VEGF165b in podocytes reduces glomerular permeability’, J Am Soc Nephrol, 21(9), (pp. 1498-1509), 2010
• Salmon, AHJ, Neal, CR & Harper, SJ. ‘New aspects of glomerular filtration barrier structure and function: five layers (at least) not three’, Curr Opin Nephrol Hypertens, 18(3), (pp. 197-205), 2009

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Recent publications

• Bills, V, Salmon, AHJ, Harper, SJ, Overton, TG, Neal, CR, Jeffery, B, Soothill, PW & Bates, DO. ‘Impaired vascular permeability regulation caused by the VEGF???b splice variant in pre-eclampsia’, BJOG, 118(10), (pp. 1253-1261), 2011
• Salmon, AHJ & Satchell, SC. ‘Endothelial glycocalyx dysfunction in disease: albuminuria and altered microvascular permeability’, Journal of Pathology, 2011
• Salmon, AHJ. ‘GPs should be vigilant for glomerulonephritis’, Practitioner, 254(1728), (pp. 27-32), 2010
• Salmon, AHJ, Neal, CR, Sage, LM, Glass, CA, Harper, SJ & Bates, DO. ‘Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx’, Cardiovasc Res, 83(1), (pp. 24-33), 2009
• Salmon, AHJ & Harper, SJ. ‘Acute Endocapillary Glomerulonephritis’, in Barratt, Harris, Topham (Ed.), Oxford Desk Reference in Nephrology, (pp. 116-119), 2009. ISBN: 0199229562
• Salmon, AHJ & Harper, SJ. ‘Membranous Glomerulonephritis’, in Barratt, Harris, Topham (Ed.), Oxford Desk Reference in Nephrology, (pp. 112-115), 2009. ISBN: 0199229562
• Salmon, AHJ & Harper, SJ. ‘Mesangiocapillary Glomerulonephritis’, in Barratt, Harris, Topham (Ed.), Oxford Desk Reference in Nephrology, (pp. 106-110), 2009. ISBN: 0199229562
• Salmon, AHJ, Toma, I, Sipos, A, Muston, PR, Harper, SJ, Bates, DO, Neal, CR & Peti-Peterdi, J. ‘Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space’, Am J Physiol Renal Physiol, 293(6), (pp. F1777-F1786), 2007

View complete publications list in the University of Bristol publications system

Networks & contacts

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