Professor Dave Bates

Research summary

I am also British Heart Foundation Senior Lecturer in Basic Biomedical Science and Scientific Director of the Microvascular Research Laboratories.

Understanding how vascular growth factors (VEGFs) regulate microvascular function is a key hurdle in developing treatments for as varied disease types as cancer, diabetes, vascular disease, psoriasis, age-related macular degeneration, and arthritis. These seemingly diverse diseases are either characterised by excessive and uncontrolled microvascular growth and permeability, such as in cancer, psoriasis, arthritis and diabetic retinopathy, or by an insufficiency of vascular growth into damaged tissue, for instance in peripheral ischaemia, diabetic ulceration and coronary ischaemia. Moreover, VEGFs are critical ...

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Selected publications

• Qiu, Y, Ferguson, J, Oltean, S, Neal, C, Kaura, A, Bevan, H, Wood, E, Sage, L, Lanati, S, Nowak, D, Salmon, A, Bates, D & Harper, S 2010, ‘Overexpression of VEGF165b in podocytes reduces glomerular permeability’. J Am Soc Nephrol, vol 21(9)., pp. 1498 - 1509
• Wu, W, Llewellyn, O, Bates, D, Nicholson, L & Dick, A 2010, ‘IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia’. Immunobiology, vol 215., pp. 796 - 803

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Recent publications

• Arkill, K, Neal, C, Mantell, J, Michel, C, Qvortrup, K, Rostgaard, J, Bates, D, Knupp, C & Squire, J 2012, ‘3D Reconstruction of the Glycocalyx Structure in Mammalian Capillaries using Electron Tomography’. Microcirculation, vol 19., pp. 343 - 351
• Bates, DO, Catalano, PJ, Symonds, KE, Varey, AHR, Ramani, P, O'Dwyer, PJ, Giantonio, BJ, Meropol, NJ, Benson, AB, Harper, SJ & Bates, DO 2012, ‘Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab’. Clinical cancer research : an official journal of the American Association for Cancer Research.

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View complete publications list in the University of Bristol publications system