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Professor Neil Marrion

Ion channel coupling and neurotranmitter release in CNS neurons

The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. In addition, the laboratory has pioneered a new technique to resolve the exocytosis of a single vesicle containing neurotransmitter. The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding to permit an appreciation of how these processes are influential in particular CNS disease states.

Research keywords

  • single channel
  • patch clamp

Diseases related to this field of research

  • Alzheimer's Disease
  • epilepsy

Processes and functions relevant to this work

  • Learning and memory
  • seizures

Equipment relevant to this work

  • Electrophysiological rigs
  • confocal microscopy

Research findings

  • Ion Channel coupling in CNS neurons
  • Pharmacology of SK channels in neurons and heart
  • Measurement of movement of a voltage-dependent ion channel upon activation and deactivation

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Collaborations

  • Jules Hancox - Bristol Ray Turner - Calgary Vincent Seutin - Liege