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Professor Neil Marrion

Professor Neil Marrion

Professor Neil Marrion
BSc, PhD(Lond)

Professor of Neuroscience

Area of research

Ion channel coupling and neurotranmitter release in CNS neurons

Office G29
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 1401

Summary

The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. In addition, the laboratory has pioneered a new technique to resolve the exocytosis of a single vesicle containing neurotransmitter. The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding to permit an appreciation of how these processes are influential in particular CNS disease states.

Activities / Findings

  • Ion Channel coupling in CNS neurons
  • Are KCNQ2/KCNQ3 channels the molecular correlates of the mammalian M-channel?
  • Monitoring vesicle exocytosis in excitable cells


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Keywords

  • single channel
  • patch clamp

Skills

  • Alzheimer's Disease
  • epilepsy

Processes and functions

  • Learning and memory
  • seizures

Methodologies

  • Patch clamp
  • Western blots
  • PCR

Links

Selected publications

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Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • MRC Centre for Synaptic Plasticity - Bristol - UK

  • Prof Graham Collingridge
    Prof Jeremy Henley
    Prof Andrew Randall

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