Professor Neil Marrion

Summary

The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. In addition, the laboratory has pioneered a new technique to resolve the exocytosis of a single vesicle containing neurotransmitter. The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding to permit an appreciation of how these processes are influential in particular CNS disease states.

Activities / Findings

• Ion Channel coupling in CNS neurons
• Are KCNQ2/KCNQ3 channels the molecular correlates of the mammalian M-channel?
• Monitoring vesicle exocytosis in excitable cells

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Keywords

• single channel
• patch clamp

Skills

• Alzheimer's Disease
• epilepsy

Processes and functions

• Learning and memory
• seizures

Methodologies

• Patch clamp
• Western blots
• PCR

Memberships

Organisations

School of Physiology and Pharmacology

MRC Centre for Synaptic Plasticity

Other sites

• Neuroscience
• Synaptic

Research Areas

• Neuropharmacology

Links

•   home page

Selected publications

• Lamy, C, Goodchild, S, Weatherall, K, Jane, D, Liégeois, J-F, Seutin, V & Marrion, N, 2010, ‘Allosteric block of KCa2 channels by apamin’. Journal of Biological Chemistry, vol 285., pp. 27067 - 27077
• Buchanan, K, Petrovic, M, Chamberlain, S, Marrion, N & Mellor, J, 2010, ‘Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors is mediated by inhibition of SK channels’. Neuron, vol 68., pp. 948 - 963
• Correa, S, Muller, R, Collingridge, G & Marrion, N, 2009, ‘Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons’. Journal of Cell Science, vol 122., pp. 4186 - 4194
• Weatherall, K, Goodchild, S, Jane, D & Marrion, N, 2010, ‘Small conductance calcium-activated potassium channels: from structure to function’. Progress in Neurobiology, vol 91., pp. 242 - 255
• Oldfield, S, Hancock, J, Mason, A, Hobson, S, Wynick, D, Kelly, E, Randall, A & Marrion, N, 2009, ‘Receptor-mediated suppression of potassium currents requires co-localization within lipid rafts’. Molecular Pharmacology, vol 76., pp. 1279-1289

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Recent publications

• Hancox, JC, James, AF, Marrion, NV, Zhang, H & Thomas, D, 2016, ‘Novel ion channel targets in atrial fibrillation’. Expert Opinion on Therapeutic Targets., pp. 1-12
• Alexander, SP, Davenport, AP, Kelly, E, Marrion, N, Peters, JA, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, Southan, C, Davies, JA & , 2015, ‘The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors’. British Journal of Pharmacology, vol 172., pp. 5744-869
• Alexander, SP, Kelly, E, Marrion, N, Peters, JA, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, Southan, C, Davies, JA & , 2015, ‘The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels’. British Journal of Pharmacology, vol 172., pp. 5942-55
• Alexander, SP, Kelly, E, Marrion, N, Peters, JA, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, Southan, C, Buneman, OP, Catterall, WA, Cidlowski, JA, Davenport, AP, Fabbro, D, Fan, G, McGrath, JC, Spedding, M, Davies, JA & , 2015, ‘The Concise Guide to PHARMACOLOGY 2015/16: Overview’. British Journal of Pharmacology, vol 172., pp. 5729-5743
• Alexander, SP, Fabbro, D, Kelly, E, Marrion, N, Peters, JA, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, Southan, C, Davies, JA & , 2015, ‘The Concise Guide to PHARMACOLOGY 2015/16: Enzymes’. British Journal of Pharmacology, vol 172., pp. 6024-109

View complete publications list in the University of Bristol publications system

Networks & contacts

• MRC Centre for Synaptic Plasticity - Bristol - UK

• Prof Graham Collingridge
  Prof Jeremy Henley
  Prof Andrew Randall