Neurones are connected together in complex networks which allow for the storage and retrieval of information. However under certain conditions, these networks are compromised, resulting in deficits in memory and cognitive processing. For example, in Alzheimer’s disease there is significant neuronal loss which results in profound changes to the remaining neuronal network. In contrast in schizophrenia, another condition which results in significant cognitive impairment, there are more subtle alterations in synaptic connectivity between, and within, different brain areas.
The cellular and synaptic mechanisms underlying these changes to neuronal circuitry are not well understood. The goal of our ...
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