Professor Jack Mellor

Research summary

Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.

We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:

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Biography

Group retreat 2017

Group retreat 2016

Group retreat 2013

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Selected publications

• Tigaret, CM, Olivo, V, Sadowski, JHL, Ashby, MC & Mellor, JR, 2016, ‘Coordinated activation of distinct Ca²⁺ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity’. Nature Communications, vol 7.
• Sadowski, JHL, Jones, M & Mellor, JR, 2016, ‘Sharp-wave ripples orchestrate the induction of synaptic plasticity during reactivation of place cell firing patterns in the hippocampus’. Cell Reports, vol 14., pp. 1916-1929

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Recent publications

• Palacios-Filardo, J & Mellor, J, 2019, ‘Neuromodulation of hippocampal long-term synaptic plasticity’. Current Opinion in Neurobiology, vol 54., pp. 37-43
• Parkinson, GT, Chamberlain, SEL, Jaafari, N, Turvey, MR, Mellor, J & Hanley, J, 2018, ‘Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit’. Scientific Reports, vol 8.

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View complete publications list in the University of Bristol publications system