How does platelet stimulation by a variety of agonists lead to activation and platelet aggregation? We are interested in elucidating the signalling pathways that are involved in platelet activation, in particular those that may play a role in platelet hyperactivity in conditions such as obesity and diabetes. Platelets are able to respond to a wide range of agonists and when activated at the site of injury they rapidly aggregate to form a platelet haemostatic plug. Increased or inappropriate platelet activation, however, will lead to thrombosis and vascular complications. Risk factors such as obesity and some genetic factors lead to a ...
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