Dr Ingeborg Hers

Research summary

How does platelet stimulation by a variety of agonists lead to activation and platelet aggregation? We are interested in elucidating the signalling pathways that are involved in platelet activation, in particular those that may play a role in platelet hyperactivity in conditions such as obesity and diabetes. Platelets are able to respond to a wide range of agonists and when activated at the site of injury they rapidly aggregate to form a platelet haemostatic plug. Increased or inappropriate platelet activation, however, will lead to thrombosis and vascular complications. Risk factors such as obesity and some genetic factors lead to a ...

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Recent publications

• Hale, LJ, Welsh, GI, Perks, CM, Hurcombe, JA, Moore, SF, Hers, I, Saleem, M, Mathieson, PW, Murphy, A, Jeansson, M, Holly, JMP, Hardouin, S & Coward, RJM 2013, ‘Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse’. Journal of Pathology, vol 230., pp. 95-106
• Moore, SF, Hunter, RW, Harper, MT, Savage, JS, Siddiq, S, Westbury, SK, Poole, AW, Mumford, AD & Hers, I 2013, ‘Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia’. BLOOD, vol 121., pp. 1209-19

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View complete publications list in the University of Bristol publications system