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Synaptic plasticity

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Neuronal plasticity is fundamental to learning and memory. Research covers a broad range of forms of plasticity in various cortical regions of the brain. Long-term potentiation (LTP) and long-term depression (LTD) are widely viewed as cellular substrates for memory mechanisms. Indeed NMDA receptor-dependent LTD has recently been shown to be the form of plasticity that underlies visual recognition memory in the perirhinal cortex. Metabotropic glutamate receptors, which were first discovered here at Bristol, play a major role in many different forms of both long- and short-term plasticity such as LTD and paired-pulse facilitation.

This area contributes to the wider Neuroscience research theme within the School of Physiology and Pharmacology.