By combining patch clamp recording and cell imaging we are investigating the processes that underly the acute and chronic effects of opioid drugs such as morphine. Currently we are seeking to determine why morphine does not induce rapid receptor desensitization and internalization, and yet does induce tolerance.
We are investigating the protein-protein interactions that take place following opioid receptor activation. Opioid receptors are coupled to G-proteins and trigger intracellular signal transduction pathways; we are focusing our attention on the role played by Protein Kinase C.
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