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Professor Graeme Henderson

Professor Graeme Henderson

Professor Graeme Henderson
BSc(Glas), MA, PhD(Aberd), Hon FBPhS, FRSB

Research Collaborator

Professor of Pharmacology

Area of research

Opioid Drug Action

Office C5/C11
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 1455
+44 (0) 117 331 1431

Summary

By combining patch clamp recording and cell imaging we are investigating the processes that underly the acute and chronic effects of opioid drugs such as morphine. Currently we are seeking to determine why morphine does not induce rapid receptor desensitization and internalization, and yet does induce tolerance.

We are investigating the protein-protein interactions that take place following opioid receptor activation. Opioid receptors are coupled to G-proteins and trigger intracellular signal transduction pathways; we are focusing our attention on the role played by Protein Kinase C.

Activities / Findings

  • Role of kinases in opioid receptor desensitization
  • Somatostatin receptor (sst2b) trafficking
  • differential activation of μ-opioid receptors induces different mechanisms of tolerance Read more >

Teaching

Vanilloid receptors, P2X receptors, G protein-coupled receptor oligomerization, RAMPs, Opioid tolerance and dependence

Keywords

  • G protein-coupled receptors
  • receptor desensitization and internalization
  • morphine
  • heroin
  • somatostatin

Skills

  • Drug addiction

Processes and functions

  • Cellular mechanisms underlying the acute action of opioid drugs and the development of tolerance and physical dependence

Methodologies

  • Electrophysiology
  • confocal imaging
  • fluorescence microscopy
  • patch clamp
  • slice preparation
  • transfection
  • ion vision microscopy
  • calcium measurements
  • flash photolysis

Links

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Dr Eamonn Kelly - School of Physiology & Pharmacology

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