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Professor Eamonn Kelly

Professor Eamonn Kelly

Professor Eamonn Kelly
BSc(Sheff), PhD(Lond)

Professor of Molecular Pharmacology

Area of research

Molecular mechanisms of desensitisation of G-protein coupled receptors

Office C5b
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1402

Research summary

There are more than 800 G protein-coupled receptors (GPCRs) in the genome and they represent a major target for clinically-prescribed drugs. Following prolonged or repeated exposure to agonist drugs that activate these receptors, the GPCRs invariably become less responsive to the agonist, a phenomenon called desensitisation. Desensitisation can limit the effectiveness of drug therapy. This group's research focuses on the molecular mechanisms of desensitisation of GPCRs.

A common mechanism of desensitisation involves phosphorylation of the GPCR by G protein-coupled receptor kinases (GRKs) or by second messenger-dependent protein kinases such as PKC and PKA. In many cases GPCR phosphorylation leads ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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