Professor David Wynick

Research summary

Galanin is a 29 amino-acid peptide that is involved in the adaptive response of the nervous system to injury and disease. It is produced and stored in a number of brain regions and the peripheral nervous system.

Following nerve injury it has been found that galanin expression increases in the neurons of the dorsal root ganglia (DRG) - clusters of sensory neurons adjacent to the spinal cord. Patients with Alzheimers disease, who have damage to those areas of the brain concerned with memory (the basal forebrain cholinergic neurons), also display elevated levels of galanin.

A number of investigators speculate that galanin ...

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Selected publications

• Wraith, D, Pope, R, Butzkueven, H, Holder, H, Vanderplank, P, Lowrey, P, Day, M, Gundlach, A, Kilpatrick, T, Scolding, N & Wynick, D 2009, ‘A role for galanin in human and experimental inflammatory demyelination’. Proceedings of the National Academy of Sciences of the United States of America, vol 106(36)., pp. 15466 - 15471
• Kerr, N, Gao, Z, Holmes, F, Hobson, S, Hancox, J, Wynick, D & James, A 2007, ‘The sodium channel Na_v1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Na_v1.5 channel’. Molecular and Cellular Neuroscience, vol 35 (2)., pp. 283 - 291

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Recent publications

• Hulse, RP, Donaldson, LF & Wynick, D 2012, ‘Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor’. Molecular Pain, vol 8., pp. 41
• Hulse, R, Donaldson, L & Wynick, D 2012, ‘Peripheral galanin receptor 2 as a target for the modulation of pain’. Pain Res Treat, vol 2012., pp. 545386 - 545386

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View complete publications list in the University of Bristol publications system