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Professor David Wynick

Professor David Wynick

Professor David Wynick
BSc, MBBS, MD(Lond), PhD(Open), FRCP

Professor of Molecular Medicine

Office Research & Innovation Department
Level 3,
University Hospitals Bristol Education Centre, Upper Maudlin Street BS2 8AE
(See a map)

+44 (0) 117 342 0584

Summary

Neuropathic pain (NP) affects about 8% of the people in the Western World and the commonest cause is diabetes mellitus. NP places an enormous emotional and financial burden on patients, carers and society. Very few NP patients obtain complete pain relief with the currently available drugs and more effective long-term therapies are urgently required. My basic-science and clinical research is focused on better understanding the mechanisms that underlie the development and maintenance of NP.

Over the last 20 years my group has identified and validated the second galanin receptor (GalR2) as a novel treatment for NP. I am now translating these findings into pre-clinical drug development for neuropathic pain by developing novel GalR2-specific ligands with the longer-term aim of taking ligands into proof-of-concept clinical studies for the treatment of painful diabetic neuropathy (PDN).

My clinical research is based on the regional PDN out-patient service I setup and run (2009-present). I see patients with complex severe refractory PDN from across the SW of England. I am currently leading on the collection of a large and well phenotyped cohort of patients with PDN which will provide sufficient power to undertake a whole-genome search for chronic pain genes and specifically to identify the genes that determine response/non-response to the current drugs used to treat PDN.

Activities / Findings

  • We have shown that galanin via activation of GalR2 appears to be an important determinant of multiple sclerosis. Read more >

Teaching

  • 50 hours/year of undergraduate medical students - bedside teaching.
  • 10 hours/year on undergraduate pharmacology and physiology courses.

Keywords

  • galanin
  • GalR2
  • DRG
  • neuropathic pain

Skills

  • neuropathic pain
  • sensory neuropathies

Recent publications

View complete publications list in the University of Bristol publications system

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