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Professor David Sheppard

Professor David Sheppard

Professor David Sheppard
B.Sc.(Brad.), Ph.D.(Cantab.)

Professor of Physiology

Office F39
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2290

Research summary

The cystic fibrosis transmembrane conductance regulator (CFTR) is a novel member of the ATP-binding cassette (ABC) transporter superfamily that forms an anion channel with complex regulation. CFTR is predominantly located in epithelia lining ducts and tubes throughout the body, although it is also expressed in some non-epithelial tissues, most notably cardiac myocytes. In epithelia, CFTR provides a pathway for the movement of chloride (Cl-) and bicarbonate anions across the apical (lumen-facing) membrane and a key point at which to regulate the rate of transepithelial salt and water transport.

Dysfunction of the CFTR Cl- channel is associated with a wide spectrum ...

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Biography

David N. Sheppard is a Reader in Physiology.  He investigates the function of CFTR, the protein product of the gene defective in cystic fibrosis (CF).  The goal of his research is to develop new drug therapies for CF patients that target the root cause of the disease.

After obtaining a PhD in Cell Physiology from the University of Cambridge with Dr. Francisco V. Sepúlveda, David worked with Prof. Michael J. Welsh at the University of Iowa in the period immediately following the demonstration that CFTR forms an epithelial chloride channel.  Returning to the UK, he was a BBSRC ...

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Selected publications

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Recent publications

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View complete publications list in the University of Bristol publications system

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