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Professor David Jane

Professor David Jane

Professor David Jane
B.A.(Cantab.), Ph.D.(Salf.), M.R.S.C.

Professor in Chemical Pharmacology

Area of research

Development of pharmacological tools for glutamate receptors

Office G24
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1409

Research summary

Glutamate receptors are the major excitatory synaptic receptors in brain and spinal cord. They are of two major types, ionotropic and metabotropic glutamate receptors.

Ionotropic glutamate receptors (iGluRs), which mediate fast synaptic responses via ion fluxes, are further subdivided into three main groups characterised by their preferential agonists N-methyl-D-aspartate (NMDA), kainate and (S)-a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA). The work of the group combines chemistry and pharmacology. We have synthesized and pharmacologically characterised a range of selective agonists and/or antagonists for each of these receptors by means of which the synaptic receptors in various brain and spinal cord pathways can be identified ...

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Selected publications

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Recent publications

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View complete publications list in the University of Bristol publications system

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