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Professor Clive Orchard

Professor Clive Orchard

Professor Clive Orchard
B.Sc., Ph.D.(Lond.), D.Sc.


Area of research

Regulation of cardiac-contraction coupling

Office DW2A
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1436

Research summary

My research is focused on cardiac excitation-contraction coupling and its regulation. Using a variety of techniques (for example voltage clamp, fluorescent ion indicators,whole cell and confocal microscopy, immunohistochemistry, RT-PCR and computer modelling) we are investigating how the rise of intracellular Ca 2+ that causes contraction is initiated, and how it is regulated by intracellular 2nd messenger pathways. A particular interest is the role of the t-tubules (invaginations of the surface membrane of cardiac ventricular myocytes) in this process. We have recently developed a technique that allows us to physically and functionally uncouple the t-tubules from the surface membrane, enabling ...

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Selected publications

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Recent publications

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