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Professor Clea Warburton

Professor Clea Warburton

Professor Clea Warburton
B.Sc.(R'dg), Ph.D.(Lond.)

Professor of Cognitive Neuroscience

Area of research

Neural substrates of learning and memory

Office G24a
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 1936

Summary

My research interests are the neural and cellular substrates of learning and memory processes in animals. I am specifically interested in the distinct contributions the perirhinal and prefrontal cortices and the hippocampal formation make to recognition memory processing.

The work conducted by my research group has involved the use of a number of complementary behavioural, pharmacological and molecular techniques to examine the neural basis of recognition memory. In earlier experiments we  revealed the differential roles played by the perirhinal cortex, hippocampus and prefrontal cortex in specific components of recognition memory, namely familiairity discrimination (our ability to tell if a stimulus such as an object, is familiar or novel); object-in-place associaitive recognition memory (our ability to tell if an object has changed its location); recency recognition memory (our ability to judge how recently an object has been encountered) .

The research uses a multidisciplinary approach incorporating molecular and cellular techniques with behavioural analysis of recognition memory. Most recently my lab have used pharmacogenetics and optogenetics to manipulate specific neural pathways between defined brain regions during specific phases of memory to uncover the nature of information processing across brain wide memory circuits.

Activities / Findings

  • Demonstration of distinct information processing pathways between the hippocampus and medial prefrontal cortex
  • The importance of the nucleus reuniens in associaitive recognition memory formation
  • Interactions between the hippocampus, prefrontal cortex and perirhinal cortex are crucial for associative recognition memory formation 
  • Long and short term recognition memory depends on different receptor mechanisms (NMDAR and KAR, respectively). Read more >
  • Both medial prefrontal and perirhinal cortical regions are required for spatial and temporal associational memory Read more >
  • Phosphorylation of CREB is necessary for recognition memory and LTP in the perirhinal cortex

Teaching

  • Director of Neuroscience Teaching
  • Level 1: Techniques in Neuroscience Unit
  • Level 2 : Lectures within the Central Nervous System Unit
  • Level 3: Seminars within the Neural Bases of Learning and Memory Unit
  • Seminars within the Brain Functions and Disorders Unit

Keywords

  • memory
  • behaviour
  • prefrontal cortex
  • hippocampus
  • perirhinal
  • nucleus reuniens
  • glutamate receptor
  • immunocytochemistry

Skills

  • Amnesia
  • Alzheimer's Disease

Processes and functions

  • Learning
  • memory

Methodologies

  • Behavioural assessment of learning and memory
  • immunocytochemistry
  • psychopharmacology
  • optogenetic and pharmacogenetic manipulations of neural circuitry

Links

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Professor James Uney
  • Professor Zafar Bashir

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