Dr Chrissy Hammond

Research summary

My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.

We have a number of projects running, including pilot experiments on the affects of gravity on the zebrafish skeletal system (with experiments to be run in hypergravity at the European Space Centre and in microgravity on the International Space Station.

We are characterising zebrafish mutants that we have generated carrying mutations to ...

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Selected publications

• E, [VE, AM, [VV, HJ, [VK, Styrkarsdottir, U, Zhu, Y, Meulenbelt, I, Lories, R, Karassa, F, Tylzanowski, P, Bos, S, Consortium, TA, Akune, , Arden, N, Carr, A, Chapman, K, Cupples, L, Dai, J, Deloukas, P, Doherty, M, Doherty, S, Engstrom, G, Gonzalez, A, Halldorsson, B, Hammond, C, Hart, D, Helgadottir, H, Hofman, A, Ikegawa, S, Ingvarsson, T, Jiang, Q, Jonsson, H, Kaprio, J, Kawaguchi, H, Kisand, K, Kloppenburg, M, Kujala, U, Lohmander, L, Loughlin, J, Luyten, F & others 2011, ‘Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22’. Annals of the Rheumatic Diseases, vol 70 (2)., pp. 349 - 355
• Spoorendonk, K, Hammond, C, Huitema, L, Vanoevelen, J & Schulte-merker, S, 2010, ‘Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging’. Journal of Applied Ichthyology, vol 26., pp. 219 - 224

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Recent publications

• Lawrence, E, Kague, E, Aggleton, J, Harniman, R, Roddy, K & Hammond, C, 2018, ‘The mechanical impact of loss of col11a2; mutant zebrafish show changes to joint shape and function which leads to early onset osteoarthritis’. Philosophical Transactions B: Biological Sciences.
• Kague, E, Witten, PE, Soenens, M, Campos, CL, Lubiana, T, Fisher, S, Hammond, C, Brown, KR, Passos-Bueno, MR & Huysseune, A, 2018, ‘Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth’. Developmental Biology, vol 435., pp. 176-184

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View complete publications list in the University of Bristol publications system