Dr Chrissy Hammond

Research summary

My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.

The lab is currently mapping and characterising a number of mutant genes, which I identified in a forward genetic screen while in the Schulte-Merker at the Hubrecht Institute in the Netherlands. All of the mutant fish generate too much bone and show loss of cartilage matrix integrity and changes to joint structure ...

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Selected publications

• E, [VE, AM, [VV, HJ, [VK, Styrkarsdottir, U, Zhu, Y, Meulenbelt, I, Lories, R, Karassa, F, Tylzanowski, P, Bos, S, Consortium, TA, Akune, , Arden, N, Carr, A, Chapman, K, Cupples, L, Dai, J, Deloukas, P, Doherty, M, Doherty, S, Engstrom, G, Gonzalez, A, Halldorsson, B, Hammond, C, Hart, D, Helgadottir, H, Hofman, A, Ikegawa, S, Ingvarsson, T, Jiang, Q, Jonsson, H, Kaprio, J, Kawaguchi, H, Kisand, K, Kloppenburg, M, Kujala, U, Lohmander, L, Loughlin, J, Luyten, F, Mabuchi, A, McCaskie, A, Nakajima, M, Nilsson, P, Nishida, N, Ollier, W, Panoutsopoulou, K, Putte, Tvd, Ralston, S, Rivadeneira, F, Saarela, J, Schulte-Merker, S, Shi, D, Slagboom, P, Sudo, A, Tamm, A, Tamm, A, Thorleifsson, G, Thorsteinsdottir, U, Tsezou, A, Wallis, G, Wilkinson, J, Yoshimura, N, Zeggini, E, Zhai, G, Zhang, F, Jonsdottir, I, Uitterlinden, A, Felson, D, Meurs, Jv, Stefansson, K, Ioannidis, J & Spector, T 2011, ‘Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22’. Annals of the Rheumatic Diseases, vol 70 (2)., pp. 349 - 355
• Spoorendonk, K, Hammond, C, Huitema, L, Vanoevelen, J & Schulte-merker, S 2010, ‘Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging’. Journal of Applied Ichthyology, vol 26., pp. 219 - 224

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Recent publications

• Hayes, AJ, Mitchell, RE, Bashford, A, Reynolds, S, Caterson, B & Hammond, CL 2013, ‘Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis’. Developmental dynamics : an official publication of the American Association of Anatomists.
• Huitema, L, Apschner, A, Logister, I, Spoorendonk, K, Bussmann, J, Hammond, CL & Schulte-Merker, S 2012, ‘Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish’. Proc. Natl. Acad. Sci, vol 109., pp. 21372-7

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View complete publications list in the University of Bristol publications system