Dr Chrissy Hammond

Research summary

My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.

We have a number of projects running, including pilot experiments on the affects of gravity on the zebrafish skeletal system (with experiments to be run in hypergravity at the European Space Centre and in microgravity on the International Space Station.

We are characterising zebrafish mutants that we have generated carrying mutations to ...

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Selected publications

• Kague, E, Hughes, SM, Lawrence, EA, Cross, S, Martin-Silverstone, E, Hammond, CL & Hinits, Y, 2019, ‘Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish’. FASEB Journal, vol 33., pp. 9116-9130
• Lawrence, E, Kague, E, Aggleton, J, Harniman, R, Roddy, K & Hammond, C, 2018, ‘The mechanical impact of loss of col11a2; mutant zebrafish show changes to joint shape and function which leads to early onset osteoarthritis’. Philosophical Transactions B: Biological Sciences, vol 373.

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Recent publications

• Newham, E, Kague, E, Aggleton, JA, Fernee, C, Brown, KR & Hammond, CL, 2019, ‘Finite Element and deformation analyses predict pattern of bone failure in loaded zebrafish spines’. Journal of the Royal Society Interface, vol 16.
• Bergen, D, Kague, E & Hammond, C, 2019, ‘Zebrafish as an emerging model for osteoporosis: a primary testing platform for screening new osteo-active compounds’. Frontiers in Endocrinology, vol 10.

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View complete publications list in the University of Bristol publications system