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Publication - Professor Alastair Poole

    Procoagulant platelets

    - generation, function and therapeutic targeting in thrombosis

    Citation

    Agbani, E & Poole, A, 2017, ‘Procoagulant platelets: - generation, function and therapeutic targeting in thrombosis’. Blood.

    Abstract

    Current understanding of how platelets localise coagulation to wound sites has come mainly from studies of a subpopulation of activated platelets. In this review we summarise data from the last four decades which has described these platelets with a range of descriptive titles and attributes. We identify striking overlaps in the reported characteristics of these platelets which imply a single subpopulation of versatile platelets, and thus suggest that their commonality requires unification of their description. We therefore propose the term procoagulant platelet as the unifying terminology. We discuss the agonist requirements and molecular drivers for the dramatic morphological transformation platelets undergo when becoming procoagulant. Finally, we provide perspectives on the biomarker potential of procoagulant platelets for thrombotic events, as well as on the possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquaporin-1 for targeting this subpopulation of platelets as antiprocoagulant antithrombotics.

    Full details in the University publications repository