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Professor Alastair Poole

Professor Alastair Poole

Professor Alastair Poole
VetMB, MA, PhD(Cantab), MRCVS

Professor of Pharmacology and Cell Biology

Area of research

Platelet Cell Biology

Office C2
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 1435
+44 (0) 117 331 1446

Summary

Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.

Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.

Activities / Findings

  • Different PKC isoforms play different roles in thrombus formation and cell adhesion ... Read more >
  • PKCα and PKCθ play opposite roles in Ca2+ handling in platelets ... Read more >

Keywords

  • platelet
  • platelet-interactive proteins
  • PKC

Skills

  • Thrombosis

Methodologies

  • FACS
  • Ca2+ imaging
  • Western Blotting
  • Immunocytochemistry
  • biochemical techniques

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

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