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Professor Sally Lawson

Professor Sally Lawson

Professor Sally Lawson
B.Sc., Ph.D.(Bristol)

Emeritus Professor

Area of research

Sensory nerve cells and their role in chronic pain states

Office G6
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 2291

Summary

Examination of the properties of nociceptive neurons, identifying neurons as nociceptive or non-nociceptive according to their responses to natural stimuli. Properties examined include membrane properties, firing patterns, ion channels and receptors determined immunocytochemically or by voltage clamp techniques. We are carefully examining how these properties alter in models of chronic pain, and thus how they may contrinute to chronic pain. This information is intended to help the much needed development of novel analgesics.

Activities / Findings

  • The study of the role of Na channel subunits in identified primary afferent neurones in normal and chronic pain states;
  • Are all trkA and IB4 positive sensory neurones nociceptive?
  • Studies of their membrane properties and relative contributions to chronic pain states.
  • The expression and role of Na channel subunits in identified primary afferent neurones in normal and chronic pain states.
  • Are all trkA and IB4 positive sensory neurones nociceptive?
  • The expression and role of K channels in identified primary afferent neurones in normal and chronic pain states.

Teaching

Sensory nervous system, pain, physiology of stress, histology

Keywords

  • ion channels
  • pain
  • nociception
  • sodium channels
  • potassium channels
  • electrophysiology
  • immunocytochemistry
  • sensory properties
  • dye injection

Skills

  • Chronic pain

Processes and functions

  • Mechanisms of pain
  • transduction
  • nociception
  • primary afferent neurons
  • ion channels

Methodologies

  • Electrophysiology
  • immunocytochemistry
  • single electrode voltage clamp
  • intracellular recording
  • dye injection
  • viral vectors
  • HSV
  • behavioural tests
  • image analysis

Links

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Professor S Waxman - USA
  • Professor J. Wood - UCL London
  • Dr. Patrick Case - Bristol
  • Professor Gordon Reid - Bucharest
  • Dr. A.A.Harper - Aberdeen

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