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Dr David Jessop

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Dr David Jessop


Dorothy Hodgkin Building, Whitson Street, Bristol
BS1 3NY
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david.jessop@bristol.ac.uk

Fax Number (0117) 331 3049
Telephone Number (0117) 331 3050
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Organisations

Medicine and Dentistry Faculty Office

School of Clinical Sciences

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Mechanisms underlying stress

Research overview

I am involved in the area of understanding how neuropeptides affect immune responses, particularly in rheumatoid arthritis. Neuropeptides such as opioids are over-expressed in the inflamed joints of patients. I am characterising how the expression of neuropeptides in inflamed joints can influence the degree and severity of inflammation. Stress can affect inflammation in rheumatoid arthritis patients and I am involved in researching how this can occur, in terms of cortisol and cytokine release.

I am also interested in defects of the Hypothalamus Pituitary Axis (HPA) in patients with RA, autism or chronic pain.

Key words

Opioids, immune system, neuropeptides, cortisol, cytokine

Key findings

  • Development of opioid peptides as anti-inflammatory agents.
  • How stress can influence degree and onset of inflammation.
  • Changes in brain cytokines in chronic inflammation.

Diseases related to this field of research

Rheumatoid arthritis, clinical depression, obesity

Processes and functions relevant to this work

Inflammation, stress, hunger and satiety

Techniques in routine use

FACS, radioimmunoassay, cell culture

Collaborations

Many international multi-laboratory collaborations, Lundbeck plc - Copenhagen Denmark

Teaching

Lecturer on MSc in Molecular Neurosciences

Public engagement

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Latest publications

  1. see Perry, MG, Jessop, DS, Hunt, LP & J R Kirwan. 'Overnight variations in interleukin-6 in synovial fluid and plasma in patients with active rheumatoid arthritis', International Journal of Clinical Rheumatology, 5, (pp. 593-600), 2011. ISSN: 1758-4272 10.2217/ijr.10.51
  2. see J R Kirwan, Clarke, LM, Hunt, LP, Perry, MG, RH Straub & Jessop, DS. 'Effect of Novel Therapeutic Glucocorticoids on Circadian Rhythms of Hormones and Cytokines in Rheumatoid Arthritis', Ann N Y Acad Sci, (pp. 127-133), 2010. ISSN: 0077-8923 10.1111/j.1749-6632.2009.05289.x
  3. see Leggett, JD, Dawe, KL, Jessop, DS & Fulford, AJ. 'Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation', Journal of Neuroendocrinology, 21(11), (pp. 888-897), 2009. ISSN: 1365-2826 10.1111/j.1365-2826.2009.01912.x
  4. see Perry, MG, J R Kirwan, Jessop, DS & Hunt, LP. 'Overnight variations in cortisol, interleukin 6, tumour necrosis factor and other cytokines in people with rheumatoid arthritis', Annals Rheumatic Diseases, 68, (pp. 63-68), 2009. ISSN: 0003-4967 10.1136/ard.2007.086561
  5. see Hasan, EA, Jessop, DS, Power, LL, Monk PT & J R Kirwan. 'Use of the dexamethasone-corticotrophin releasing factor test to assess hypothalamic-pituitary-adrenal axis function in rheumatoid arthritis', Journal of Endocrinology, (pp. -), 2009. 10.1155/2009/391284
  6. see Straub, RH, Wolff, C, Fassold, A, Hofbauer, R, Chover-Gonzalez, A, Richards, LJ & Jessop, DS. 'Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant-induced polyarthritis', Arthritis and Rheumatism, 58 (2), (pp. 456-466), 2008. ISSN: 0004-3591 10.1002/art.23206
  7. see Lolait, SJ, Stewart, LQ, Jessop, DS, Young 3rd, WS & O'Carroll, A-M. 'The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors', Endocrinology, 148 (2), (pp. 849-856), 2007. ISSN: 0013-7227 10.1210/en.2006-1309
  8. see Leggett, JD, Jessop, DS & Fulford, AJ. 'The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm', Neuroscience, 147 (3), (pp. 757-764), 2007. ISSN: 0306-4522 10.1016/j.neuroscience.2007.04.010
  9. see Hesketh, SA, Leggett, JD & Jessop, DS. 'Chronic citalopram treatment does not sensitise the adrenal gland to ACTH (1-24) in rats', Journal of Psychopharmacology, 21 (8), (pp. 885-887), 2007. ISSN: 0269-8811 10.1177/0269881107078310
  10. see Lolait, SJ, Stewart, LQ, Roper, J, Harrison, G, Jessop, DS, Young III, WS & O'Carroll, A-M. 'Attenuated stress response to acute lipopolysaccharide challenge and ethanol administration in vasopressin V1b receptor knockout mice', Journal of Neuroendocrinology, 19 (7), (pp. 543-551), 2007. ISSN: 0953-8194 10.1111/j.1365-2826.2007.01560.x

Full publications list in the University of Bristol publications system

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