Professor Neil Scolding

Photo of Professor Neil Scolding

Professor Neil Scolding

Inst. of Clinical Neurosciences, Department of Neurology, Frenchay Hospital
BS16 1LE
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n.j.scolding@bristol.ac.uk

Telephone Number (0117) 34 06632

Organisations

School of Clinical Sciences

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Research overview

Neil Scolding is the Burden Professor and Director of the Bristol Institute of Clinical Neurosciences; he is currently based at Frenchay Hospital.

He trained in Neurology in Cardiff and at the National Hospital for Neurology and Neurosurgery, Queen Square, and was a University Lecturer and Consultant Neurologist in Cambridge before coming to Bristol as the Foundation Burden chairholder in 1999.

Neil has a clinical and research interest in the biology of multiple sclerosis and in particular in  the clinical and experimental exploration of cell-based treatments designed to protect and repair the brain and spinal cord in patients with disability from MS. In addition, he has interests in other forms of inflammation in the nervous system, including vasculitis and sarcoidosis.

Key words

stem-cell, myelin, neurology, transplantation, regeneration, neuronal precursors

Diseases related to this field of research

Multiple Sclerosis

Processes and functions relevant to this work

Myelination

Techniques in routine use

Confocal imaging, Cell Culture

Equipment in routine use

Confocal Imaging System

Collaborations

David Wraith




Latest publications

  1. Gray, E, Kemp, KC, Hares, KM, Redondo, J, Rice, CM, Scolding, NJ & Wilkins, A 2014, ‘Increased microglial catalase activity in multiple sclerosis grey matter’. Brain Research.
  2. Rice, CM, Kemp, KC, Wilkins, A & Scolding, NJ 2013, ‘Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases’. Lancet, vol 382., pp. 1204-1213
  3. Hares, KM, Kemp, KC, Rice, CM, Gray, E, Scolding, NJ & Wilkins, A 2013, ‘Reduced axonal motor protein expression in non-lesional grey matter in multiple sclerosis’. Multiple Sclerosis Journal.
  4. Gray, E, Rice, C, Nightingale, H, Ginty, M, Hares, K, Kemp, K, Cohen, N, Love, S, Scolding, N & Wilkins, A 2013, ‘Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis’. Multiple sclerosis (Houndmills, Basingstoke, England), vol 19., pp. 153-161
  5. Gray, E, Rice, CM, Hares, KM, Redondo, J, Kemp, KC, Williams, M, Brown, A, Scolding, NJ & Wilkins, A 2013, ‘Reductions in neuronal peroxisomes in multiple sclerosis grey matter’. Multiple Sclerosis Journal.
  6. Rice, CM, Cottrell, DA, Wilkins, A & Scolding, NJ 2013, ‘Primary progressive multiple sclerosis – progress and challenges’. Journal of Neurology, Neurosurgery & Psychiatry, vol 84., pp. 1100-6
  7. Rice, CM, Gray, E, Hares, KM, Kemp, KC, Sun, M, Ginty, M, Barizien, S, Wilkins, A & Scolding, NJ 2013, ‘SIRT3 expression is reduced in non-lesional grey matter in multiple sclerosis’. in: Neuropathology and Applied Neurobiology., pp. 7-26
  8. Rice, C, Sun, M, Kemp, K, Gray, E, Wilkins, A & Scolding, N 2012, ‘Mitochondrial sirtuins −a new therapeutic target for repair and protection in multiple sclerosis’. European Journal of Neuroscience, vol 35., pp. 1887-93
  9. Whone, AL, Kemp, K, Sun, M, Wilkins, A & Scolding, NJ 2012, ‘Human bone marrow mesenchymal stem cells protect catecholaminergic and serotonergic neuronal perikarya and transporter function from oxidative stress by the secretion of glial-derived neurotrophic factor’. Brain Research, vol 1431., pp. 86-96
  10. Rice, CM, Ramamoorthi, M, Renowden, SA, Heywood, P, Whone, AL & Scolding, NJ 2012, ‘Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis’. QJM : monthly journal of the Association of Physicians, vol 105., pp. 473 - 475

Full publications list in the University of Bristol publications system

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