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Professor Julian Paton

Professor Julian Paton

Professor Julian Paton
BSc(Birm), PhD(Lond)

Professorial Research Fellow in Physiology

Area of research

Mechanisms of neurogenic hypertension

Office E10 / E9
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2275

Research summary

Paton's group seeks to understand what changes within the central nervous system during the aetiology of neurogenic hypertension. Sympathetic nerve activity destined for the heart and arterioles is elevated prior to the onset of hypertension, which is suggestive of a causative role. In hypertension, cerebral vascular resistance is elevated causing brain hypoperfusion - a well known stimulant of sympathetic activity and hypertension. The microvasculature of the brainstem is also inflamed.

The hypothesis of elevated brainstem vascular resistance and inflammation as causative to hypertension is being explored in animal models and human patients. Transcriptomic analysis of brainstem genes altered in hypertension ...

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Selected publications

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Recent publications

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View complete publications list in the University of Bristol publications system

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