Inflammation and Immunology
The mechanism of leukocyte and stem migration into sites of inflammation is fundamental to all inflammatory diseases such as periodontitis of the gums and rheumatoid arthritis. Chemokines are cytokines that function by stimulating leukocytes to migrate across endothelial cells and into inflamed tissues. By understanding these mechanisms the aim is to identify which molecules to target therapeutically.
Endothelial cells and leukocytes
In order for leukocytes to leave the blood they need to adhere to the luminal surface of endothelial cells, migrate across these cells, and enter tissues. Chemokines are involved in both of these mechanisms, and exert ...
BSc in Applied Biology from Bath University and PhD in cartilage biochemistry and ultrastructure from Lancaster University. Postdoctoral positions were at Strangeways Research Laboratory Cambridge and Bath University. Senior Scientist in immunopharmacology at Novartis Research Institute, Vienna. Senior Lecturer, Reader, then Professor and Head of Arthritis Research at the RJAH Orthopaedic Hospital, Oswestry which is part of the Medical School, Keele University. Visiting professor at Endocube, a biotech company in Toulouse, France. Consultant for GlaxoSmithKline. Joined Bristol University in Sept 2010 and became Professor and Reader in Cellular Immunology and Head of Inflammation and Immunology group, School of Oral ...
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