The virulence of pathogenic bacteria relies on their ability to induce signals within host-cells to alter their behaviour. This can involve surface expression of proteins, secretion of toxins or, in some of the most interesting examples, direct transfer of proteins by bacteria into host-cells. The molecular mechanisms underlying bacterial modulation of host cells have yet to be fully defined. My group?s research focuses on the molecular mechanisms underlying the cross-talk between pathogenic bacteria with epithelial cells. Our work has principally focused on Salmonella and enteropathogenic E. coli (EPEC) but newer projects have extended our research interests to encompass also Campylobacter, Streptococci and EHEC. Specific areas of interest include: 1) understanding how bacteria modulate the actin cytoskeleton and intracellular trafficking; 2) understanding how bacteria alter epithelial permeability; 3) defining the role of particle-transporting epithelial cells (M cells) in bacterial infection; 4) applying cell imaging techniques to the study of microbial pathogenesis.
Expertise key words
pathogenic bacteriaproteinstoxinsbacteriabacterial modulationmolecular mechanismsepithelial cells
- Jauregui, C, Mansell, JP, Jepson, MA & Jenkinson, HF 2012, Differential interactions of Streptococcus gordonii and Staphylococcus aureus with cultured osteoblasts. Molecular Oral Microbiology.
- Baalousha, M, Ju-Nam, Y, Cole, P, Hriljac, J, Jones, I, Tyler, C, Stone, V, Fernandes, T, Jepson, M & Lead, J 2012, Characterization of cerium oxide nanoparticles. Part 2: Nonsize measurements. Environmental Toxicology and Chemistry, vol 31(5)., pp. 994 - 1003
- Gaiser, B, Fernandes, T, Jepson, M, Lead, J, Tyler, C, Baalousha, M, Biswas, A, Britton, G, Cole, P, Johnston, B, Ju-Nam, Y, Rosenkranz, P, Scown, T & Stone, V 2012, Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environmental Toxicology and Chemistry, vol 31(1)., pp. 144 - 154
- Baalousha, M, Ju-Nam, Y, Cole, P, Gaiser, B, Fernandes, T, Hriljac, J, Jepson, M, Stone, V, Tyler, C & Lead, J 2012, Characterization of cerium oxide nanoparticles. Part 1: Size measurements. Environmental Toxicology and Chemistry, vol 31(5)., pp. 983 - 993
- Maddocks, S, Wright, C, Nobbs, A, Brittan, J, Franklin, L, Stromberg, N, Kadioglu, A, Jepson, M & Jenkinson, H 2011, Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Molecular Microbiology, vol 81., pp. 1034-1049
- Humphrey, S, MacVicar, T, Stevenson, A, Roberts, M, Humphrey, T & Jepson, M 2011, SulA-induced filamentation in Salmonella enterica serovar Typhimurium: effects on SPI-1 expression and epithelial infection. Journal of Applied Microbiology, vol 111 (5)., pp. 185 - 196
- Clark, L, Perrett, C, Malt, L, Harward, C, Humphrey, S, Jepson, K, Martinez-Argudo, I, Carney, L, Ragione, RL, Humphrey, T & Jepson, M 2011, Differences in Salmonella enterica serovar Typhimurium strain invasiveness are associated with heterogeneity in SPI-1 gene expression. Microbiology, vol 157 (7)., pp. 2072 - 2083
- Gaiser, B, Biswas, A, Rosenkranz, P, Jepson, M, Lead, J, Stone, V, Tyler, C & Fernandes, T 2011, Effects of silver and cerium dioxide micro- and nano-sized particles on Daphnia magna. Journal of Environmental Monitoring, vol 13 (5)., pp. 1227 - 1235
- King, M, Jepson, M, Guest, A & Mushens, R 2011, Detection of hereditary pyropoikilocytosis by teh eosin-5-maleimide (EMA)-binding test is attributable to a marked reduction in EMS-ractive transmembrane proteins. International Journal of Laboratory Hematology, vol 33 (2)., pp. 205 - 211
- Humphrey, S, Clark, L, Humphrey, T & Jepson, M 2011, Enhanced recovery of Salmonella typhimurium DT104 from exposure to stress at low temperature. Microbiology, vol 157 (4)., pp. 1103 - 1114
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