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Microbial pathogenesis and antimicrobial resistance

Microbial infections remain a major cause of morbidity and mortality throughout the world. Understanding the molecular basis of interactions between microbes and host cells, and the mechanisms by which tissue damage occurs directly, or by adversely stimulating the immune system, is central to the development of next generation antimicrobial products. This work benefits from strong links with Bristol’s hospitals through the Bristol Centre for Antimicrobial Research and Evaluation (BCARE). Collaborations with the Department of Social Medicine pursue the epidemiology of infectious disease and the impact that vaccination and screening has on the course of these diseases.