Browse by:

Controlling immune regulation to promote heath

A healthy immune system negotiates successfully with the infectious environment, providing effective resistance to dangerous infection and careful surveillance for developing cancer. When this balance is disturbed, different diseases develop. Autoimmune disease leads to immune attack directed towards healthy tissues, and current treatments use global immune suppression that leaves patients at risk of infection. Cancers resist immune attack by subverting normal mechanisms of tolerance and regulation. Research in this area focuses both on developing more focused therapies for autoimmunity, better understanding of how autoimmune disease progresses, and insight into mechanisms used by cancer to avoid immune attack