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Publication - Dr Borko Amulic

    Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression

    Citation

    Sollberger, G, Amulic, B & Zychlinsky, A, 2016, ‘Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression’. PLoS ONE, vol 11., pp. e0157454

    Abstract

    Neutrophils are essential innate immune cells whose responses are crucial in the clearance of invading pathogens. Neutrophils can respond to infection by releasing neutrophil extracellular traps (NETs). NETs are formed of chromatin and specific granular proteins and are released after execution of a poorly characterized cell death pathway. Here, we show that NET formation induced by PMA or Candida albicans is independent of RNA polymerase II and III-mediated transcription as well as of protein synthesis. Thus, neutrophils contain all the factors required for NET formation when they emerge from the bone marrow as differentiated cells.

    Full details in the University publications repository