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Publication - Dr Rosalyn Moran

    Dynamic causal modelling of seizure activity in a rat model


    Papadopoulou, M, Cooray, G, Rosch, R, Moran, R, Marinazzo, D & Friston, K, 2017, ‘Dynamic causal modelling of seizure activity in a rat model’. NeuroImage, vol 146., pp. 518-532


    This paper presents a physiological account of seizure activity and its evolution over time using a rat model of induced epilepsy. We analyse spectral activity recorded in the hippocampi of three rats who received kainic acid injections in the right hippocampus .We use dynamic causal modelling of seizure activity and Bayesian model reduction to identify the key synaptic and activity parameters that underlie seizure onset. Using recent advances in hierarchical modelling (parametric empirical Bayes), we characterise seizure onset in terms of slow fluctuations in synaptic excitability of specific neuronal populations. Our results suggest differences in the pathophysiology of seizure activity in the lesioned versus the non-lesioned hippocampus – with larger changes in inhibition, excitation and temporal summation on the lesioned side.

    Full details in the University publications repository