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Dr Angela Nobbs

Mechanisms of streptococcal colonization and pathogenesis

Dr. Angela Nobbs is a Lecturer in Oral Microbiology within the School of Oral and Dental Sciences. Her research interests focus on the mechanisms by which Streptococcus bacteria are able to colonize and cause disease within the human host. These include determining the molecular basis of streptococcal interactions with other members of the oral microflora, such as the fungus Candida albicans, and with host epithelial and endothelial cells, in terms of adherence/invasion, biofilm formation and modulation of cell signalling responses.

Research keywords

  • Oral Microbiology
  • Dental Sciences
  • Microbial Adherence
  • Microbial Pathogenesis
  • Microbial Surface Proteins
  • Biofilms
  • Streptococcus
  • Candida albicans
  • Genetics of streptococci and Candida
  • Epithelial/endothelial cell interactions

Diseases related to this field of research

  • Tonsillitis
  • Pharyngitis
  • Pneumonia
  • Meningitis
  • Septicaemia
  • Cardiovascular disease
  • Infective endocarditis
  • Atherosclerosis
  • Disseminated intravascular coagulation
  • Periodontitis
  • Gingivitis
  • Dental caries
  • Stomatitis
  • Candidosis

Processes and functions relevant to this work

  • Molecular microbiology
  • Cellular microbiology
  • Protein structure and function

Collaborations

  • UoB - Howard Jenkinson
  • Dave Dymock
  • Mark Jepson
  • Jim Middleton